Students / Alumni Publications
2024
Kochan, S. M. V., Malo, M. C., Jevtic, M., Jahn-Kelleter, H. M., Wani, G. A., Ndoci, K., Perez-Revuelta, L., Gaedke, F., Schaffner, I., Lie, D. C., Schauss, A.andBergami, M., “Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons”, Neuron, 2024. https://doi.org/10.1016/j.neuron.2024.03.013
Longarini, E. J. and Dauben, H., “Deciphering ADP-ribosylation signalling”, Nat Rev Mol Cell Biol, 25(1),p. 3-3, 2024. https://doi.org/10.1038/s41580-023-00630-x
Peil, J., Vossen, C., Bock, F., Clahsen, T., Schiller, P., Heindl, L. M., Bosch, J. J., Wunderlich, F. T., Cursiefen, C. and Schlereth, S. L., “Combined Osteopontin Blockade and Type 2 Classical Dendritic Cell Vaccination as Effective Synergetic Therapy for Conjunctival Melanoma”, J Immunol, 212(3),p. 487-499, 2024. https://doi.org/10.4049/jimmunol.2300063
Ramos, C., Bonasera, D., Saggau, J., Kabiljo, J., Lin, P., Tishina, S. and Rincon, M. G., “12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration”, Biochim Biophys Acta Mol Cell Res, 1871(3),p. 119677, 2024. https://doi.org/10.1016/j.bbamcr.2024.119677
Vossen, C., Schmidt, P., Wunderlich, C. M., Mittenbuhler, M. J., Tapken, C., Wienand, P., Mirabella, P. N., Cabot, L., Schumacher, A. L., Folz-Donahue, K., Kukat, C., Voigt, I., Bruning, J. C., Fenselau, H. and Wunderlich, F. T., “An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice”, Cells, 13(1),p. 2024. https://doi.org/10.3390/cells13010102
Wagener, R., Brandes, D., Jung, M., Huetzen, M. A., Bergmann, A. K., Panier, S., Picard, D., Fischer, U., Jachimowicz, R. D., Borkhardt, A. & Brozou, T., “Optical genome mapping identifies structural variants in potentially new cancer predisposition candidate genes in pediatric cancer patients”, Int J Cancer, 154(4),p. 607-614, 2024. https://doi.org/10.1002/ijc.34721
2023
Artoni, F., Grutzmacher, N., and Demetriades, C., “Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor”, Aging Cell, 22(8),p. e13888, 2023. https://doi.org/10.1111/acel.13888
Averdunk, L., Huetzen, M.A., Moreno-Andres, D., Kalb, R., McKee, S., Hsieh, T.C., Seibt, A., Schouwink, M., Lalani, S., Faqeih, E.A., Brunet, T., Boor, P., Neveling, K., Hoischen, A., Hildebrandt, B., Graf, E., Lu, L., Jin, W., Schaper, J., Omer, J.A., Demaret, T., Fleischer, N., Schindler, D., Krawitz, P., Mayatepek, E., Wieczorek, D., Wang, L.L., Antonin, W., Jachimowicz, R.D., von Felbert, V., and Distelmaier, F., “Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence”, Genet Med: p. 100836 2023. https://doi.org/10.1016/j.gim.2023.100836
Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D.J., Gronke, S., and Partridge, L., “Reduced insulin signaling in neurons induces sex-specific health benefits”, Sci Adv, 9(8): p. eade8137 2023. https://doi.org/10.1126/sciadv.ade8137
Bujarrabal-Dueso, A., Sendtner, G., Meyer, D.H., Chatzinikolaou, G., Stratigi, K., Garinis, G.A., and Schumacher, B., “The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities”, Nat Struct Mol Biol, 2023. https://doi.org/10.1038/s41594-023-00942-8
Cabot, L., Erlenbeck-Dinkelmann, J., and Fenselau, H., “Neural gut-to-brain communication for postprandial control of satiation and glucose metabolism”, J Endocrinol, 258(3),p. 2023. https://doi.org/10.1530/JOE-22-0320
Dauben, H., Longarini, E. J., and Matic, I., “A chemical biology/modular antibody platform for ADP-ribosylation signaling”, Trends Biochem Sci, 48(10),p. 910-911, 2023. https://doi.org/10.1016/j.tibs.2023.06.005
Deshwal, S., Onishi, M., Tatsuta, T., Bartsch, T., Cors, E., Ried, K., Lemke, K., Nolte, H., Giavalisco, P., and Langer, T., “Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7”, Nat Cell Biol, 25(2): p. 246-257 2023. https://doi.org/10.1038/s41556-022-01071-y
Dolfi, L., Ripa, R., Medelbekova, D., Ballhysa, E., Symmons, O., and Antebi, A., “Nonlethal Blood Sampling from the Killifish Nothobranchius furzeri”, Cold Spring Harb Protoc, 2023. https://doi.org/10.1101/pdb.prot107745
Dolfi, L., Suen, T. K., Medelbekova, D., Ripa, R., Symmons, O. & Antebi, A., “Sperm Cryopreservation of the African Turquoise Killifish Nothobranchius furzeri”, Cold Spring HarbProtoc, 2023(11),p. pdb prot107885, 2023. https://doi.org/10.1101/pdb.prot107885
Dolfi, L., Suen, T. K., Medelbekova, D., Ripa, R., Symmons, O., and Antebi, A., “In Vitro Fertilization of the African Turquoise Killifish Nothobranchius furzeri”, Cold Spring Harb Protoc, 2023(11),p. pdb prot107886, 2023. https://doi.org/10.1101/pdb.prot107886
Flumann, R., Hansen, J., Meinel, J., Pfeiffer, P., Goldfarb Wittkopf, H., Lutz, A., Wirtz, J., Mollmann, M., Zhou, T., Tabatabai, A., Lohmann, T., Jauch, M., Beleggia, F., Pelzer, B., Ullrich, F., Hofmann, S., Arora, A., Persigehl, T., Buettner, R., von Tresckow, B., Klein, S., Jachimowicz, R. D., Reinhardt, H. C. P. & Knittel, G., “An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma”, Blood Adv, 2023. https://doi.org/10.1182/bloodadvances.2023011213
Flumann, R., Hansen, J., Pelzer, B.W., Nieper, P., Lohmann, T., Kisis, I., Riet, T., Kohlhas, V., Nguyen, P.H., Peifer, M., Abedpour, N., Bosco, G., Thomas, R.K., Kochanek, M., Knufer, J., Jonigkeit, L., Beleggia, F., Holzem, A., Buttner, R., Lohneis, P., Meinel, J., Ortmann, M., Persigehl, T., Hallek, M., Calado, D.P., Chmielewski, M., Klein, S., Gothert, J.R., Chapuy, B., Zevnik, B., Wunderlich, F.T., von Tresckow, B., Jachimowicz, R.D., Melnick, A.M., Reinhardt, H.C., and Knittel, G., “Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies”, Blood Cancer Discov, 4(1): p. 78-97 2023. https://doi.org/10.1158/2643-3230.BCD-22-0007
Gallrein, C., Williams, A. B., Meyer, D. H., Messling, J. E., Garcia, A., and Schumacher, B., “baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism”, Cell Rep, 42(12),p. 113577, 2023. https://doi.org/10.1016/j.celrep.2023.113577
Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona-Perez, A. J., Deshwal, S., Giavalisco, P., Langer, T., and MacVicar, T., “Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression”, EMBO J, e113256, 2023. https://doi.org/10.15252/embj.2022113256
Gutierrez-Garcia, R., Koyuncu, S., Hommen, F., Bilican, S., Lee, H.J., Fatima, A., and Vilchez, D., “G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly”, Hum Mol Genet, 2023. https://doi.org/10.1093/hmg/ddac304
Hagmann, H., Khayyat, N.H., Matin, M., Oezel, C., Chen, H., Schauss, A., Schell, C., Benzing, T., Dryer, S., and Brinkkoetter, P.T., “Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy”, Cells, 12(2): p. 271 2023. https://doi.org/10.3390/cells12020271
Hammerschmidt, P., Steculorum, S. M., Bandet, C. L., Del Rio-Martin, A., Steuernagel, L., Kohlhaas, V., Feldmann, M., Varela, L., Majcher, A., Quatorze Correia, M., Klar, R. F. U., Bauder, C. A., Kaya, E., Porniece, M., Biglari, N., Sieben, A., Horvath, T. L., Hornemann, T., Brodesser, S., and Bruning, J. C., “CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice”, Nat Commun, 14(1),p. 7824, 2023. https://doi.org/10.1038/s41467-023-42595-7
Johns, A., Higuchi-Sanabria, R., Thorwald, M.A., and Vilchez, D., “A tale of two pathways: Regulation of proteostasis by UPR(mt) and MDPs”, Curr Opin Neurobiol, 78: p. 102673 2023. https://doi.org/10.1016/j.conb.2022.102673
Kohle, F., Ackfeld, R., Hommen, F., Klein, I., Svacina, M. K. R., Schneider, C., Fink, G. R., Barham, M., Vilchez, D., and Lehmann, H. C., “Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis”, J Neuroinflammation, 20(1),p. 139, 2023. https://doi.org/10.1186/s12974-023-02822-w
Lee, H.J., Alirzayeva, H., Koyuncu, S., Rueber, A., Noormohammadi, A., and Vilchez, D., “Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes”, Nature Aging, 2023. https://doi.org/10.1038/s43587-023-00383-4
Llamas, E., Koyuncu, S., Lee, H. J., Wehrmann, M., Gutierrez-Garcia, R., Dunken, N., Charura, N., Torres-Montilla, S., Schlimgen, E., Mandel, A. M., Theile, E. B., Grossbach, J., Wagle, P., Lackmann, J. W., Schermer, B., Benzing, T., Beyer, A., Pulido, P., Rodriguez-Concepcion, M., Zuccaro, A., and Vilchez, D., “In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation”, Nat Aging, 3(11),p. 1345-1357, 2023. https://doi.org/10.1038/s43587-023-00502-1
Longarini, E. J., Dauben, H., Locatelli, C., Wondisford, A. R., Smith, R., Muench, C., Kolvenbach, A., Lynskey, M. L., Pope, A., Bonfiglio, J. J., Jurado, E. P., Fajka-Boja, R., Colby, T., Schuller, M., Ahel, I., Timinszky, G., O'Sullivan, R. J., Huet, S., and Matic, I., “Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling”, Mol Cell, 83(10),p. 1743-1760 e1711, 2023. https://doi.org/10.1016/j.molcel.2023.03.027
Mandato, E., Yan, Q., Ouyang, J., Paczkowska, J., Qin, Y., Hao, Y., Bojarczuk, K., Hansen, J., Chapuy, B., Rodig, S. J., Khan, S. J., Redd, R. A., and Shipp, M. A., “MYD88L265P Augments Proximal B-Cell Receptor Signaling in Large B-Cell Lymphomas Via an Interaction with DOCK8”, Blood, 2023. https://doi.org/10.1182/blood.2023019865
Martinez-Osorio, V., Abdelwahab, Y., and Ros, U., “The Many Faces of MLKL, the Executor of Necroptosis”, Int J Mol Sci, 24(12),p. 2023. https://doi.org/10.3390/ijms241210108
Mehra, C. and Pernas, L., “Contact sites between host organelles and pathogens: boon or bane?”, mSphere, 8(6),p. e0044823, 2023. https://doi.org/10.1128/msphere.00448-23
Muller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernandez, L., Bragelmann, J., Leprivier, G., and von Karstedt, S., “Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation”, Cell Death Differ, 30(2): p. 442-456 2023. https://doi.org/10.1038/s41418-022-01096-8
Nikopoulou, C., Kleinenkuhnen, N., Parekh, S., Sandoval, T., Ziegenhain, C., Schneider, F., Giavalisco, P., Donahue, K. F., Vesting, A. J., Kirchner, M., Bozukova, M., Vossen, C., Altmuller, J., Wunderlich, T., Sandberg, R., Kondylis, V., Tresch, A., and Tessarz, P., “Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver”, Nat Aging, 3(11),p. 1430-1445, 2023. https://doi.org/10.1038/s43587-023-00513-y
Ottens, F., Efstathiou, S., and Hoppe, T., “Cutting through the stress: RNA decay pathways at the endoplasmic reticulum”, Trends Cell Biol, 2023. https://doi.org/10.1016/j.tcb.2023.11.003
Ripa, R., Ballhysa, E., Steiner, J. D., Laboy, R., Annibal, A., Hochhard, N., Latza, C., Dolfi, L., Calabrese, C., Meyer, A. M., Polidori, M. C., Muller, R. U., and Antebi, A., “Refeeding-associated AMPK(gamma1) complex activity is a hallmark of health and longevity”, Nat Aging, 3(12),p. 1544-1560, 2023. https://doi.org/10.1038/s43587-023-00521-y
Ripa, R., Mesaros, A., Symmons, O., Ballhysa, E., Dolfi, L., and Antebi, A., “Micro-CT Analysis of Fat in the Killifish Nothobranchius furzeri”, Cold Spring Harb Protoc, 2023. https://doi.org/10.1101/pdb.prot107884
Rivera-Mejias, P., Narbona-Perez, A.J., Hasberg, L., Kroczek, L., Bahat, A., Lawo, S., Folz-Donahue, K., Schumacher, A.L., Ahola, S., Mayer, F.C., Giavalisco, P., Nolte, H., Lavandero, S., and Langer, T., “The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage”, Cell Rep, 42(4): p. 112332 2023. https://doi.org/10.1016/j.celrep.2023.112332
Rozsivalova, D.H., Popovic, M., Kaul, H., and Trifunovic, A., “Isolation of Functional Mitochondria and Pure mtDNA from Murine Tissues”, Methods Mol Biol, 2615: p. 3-16 2023. https://doi.org/10.1007/978-1-0716-2922-2_1
Rubio, K., Müller, J. M., Mehta, A., Watermann, I., Olchers, T., Koch, I., Wessels, S., Schneider, M. A., Araujo-Ramos, T., Singh, I., Kugler, C., Stoleriu, M. G., Kriegsmann, M., Eichhorn, M., Muley, T., Merkel, O. M., Braun, T., Ammerpohl, O., Reck, M., Tresch, A., and Barreto, G., “Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score”, Discover Oncology, 14(1),p. 181, 2023. https://doi.org/10.1007/s12672-023-00799-9
Seidel, J., Bradshaw, W.J., and Valenzano, D.R., “Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish (Nothobranchius furzeri)”, Cold Spring Harb Protoc, 2023. https://doi.org/10.1101/pdb.prot107750
Selle, J., Bohl, K., Hopker, K., Wilke, R., Dinger, K., Kasper, P., Abend, B., Schermer, B., Muller, R.U., Kurschat, C., Nusken, K.D., Nusken, E., Meyer, D., Savai Pullamsetti, S., Schumacher, B., Dotsch, J., and Alcazar, M.A.A., “Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling”, Int J Mol Sci, 24(3): p. 2508 2023. https://doi.org/10.3390/ijms24032508
Stankovic, D., Csordas, G., and Uhlirova, M., “Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes”, Life Sci Alliance, 6(2): p. e202201801 2023. https://doi.org/10.26508/lsa.202201801
Steiner, J.D., Annibal, A., Laboy, R., Braumann, M., Gobel, H., Laasch, V., Muller, R.U., Spath, M.R., Antebi, A., and Kubacki, T., “A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature”, Rheumatology (Oxford): p. kead068 2023. https://doi.org/10.1093/rheumatology/kead068
Tabatabai, A., Arora, A., Hofmann, S., Jauch, M., von Tresckow, B., Hansen, J., Flumann, R., Jachimowicz, R. D., Klein, S., Reinhardt, H. C., and Knittel, G., “Mouse models of diffuse large B cell lymphoma”, Front Immunol, 14(1313371), 2023. https://doi.org/10.3389/fimmu.2023.1313371
Venturutti, L., Rivas, M. A., Pelzer, B. W., Flumann, R., Hansen, J., Karagiannidis, I., Xia, M., McNally, D. R., Isshiki, Y., Lytle, A., Teater, M., Chin, C. R., Meydan, C., Knittel, G., Ricker, E., Mason, C. E., Ye, X., Pan-Hammarstrom, Q., Steidl, C., Scott, D. W., Reinhardt, H. C., Pernis, A. B., Beguelin, W., and Melnick, A. M., “An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas”, Cancer Discov, 13(1),p. 216-243, 2023. https://doi.org/10.1158/2159-8290.CD-22-0561
Wang, S., Meyer, D.H., and Schumacher, B., “Inheritance of paternal DNA damage by histone-mediated repair restriction”, Nature, 613(7943): p. 365-374 2023. https://doi.org/10.1038/s41586-022-05544-w
Wehrmann, M. and Vilchez, D., “The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes”, Front Immunol, 14(1303072), 2023. https://doi.org/10.3389/fimmu.2023.1303072
Wester, L.E., Lanjuin, A., Bruckisch, E.H.W., Perez-Matos, M.C., Stine, P.G., Heintz, C., Denzel, M.S., and Mair, W.B., “A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans”, Cell Rep Methods, 3(3): p. 100433 2023. https://doi.org/10.1016/j.crmeth.2023.100433
2022
Allmeroth, K., Hartman, M.D., Purrio, M., Mesaros, A., and Denzel, M.S., “Hexosamine pathway activation improves memory but does not extend lifespan in mice”, Aging Cell, 21(10): p. e13711 2022. https://doi.org/10.1111/acel.13711
Baghdadi, M., Hinterding, H.M., Partridge, L., and Deelen, J., “From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing”, Brief Funct Genomics, 21(1): p. 13-23 2022. https://doi.org/10.1093/bfgp/elab005
Balaji, V., Muller, L., Lorenz, R., Kevei, E., Zhang, W.H., Santiago, U., Gebauer, J., Llamas, E., Vilchez, D., Camacho, C.J., Pokrzywa, W., and Hoppe, T., “A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing”, Mol Cell, 82(17): p. 3239-3254 e11 2022. https://doi.org/10.1016/j.molcel.2022.08.003
Bozukova, M., Nikopoulou, C., Kleinenkuhnen, N., Grbavac, D., Goetsch, K., and Tessarz, P., “Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver”, Mol Syst Biol, 18(9): p. e11002 2022. https://doi.org/10.15252/msb.202211002
Bradshaw, W.J., Poeschla, M., Placzek, A., Kean, S., and Valenzano, D.R., “Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish”, Elife, 11: p. e65117 2022. https://doi.org/10.7554/eLife.65117
Croon, M., Szczepanowska, K., Popovic, M., Lienkamp, C., Senft, K., Brandscheid, C.P., Bock, T., Gnatzy-Feik, L., Ashurov, A., Acton, R.J., Kaul, H., Pujol, C., Rosenkranz, S., Kruger, M., and Trifunovic, A., “FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction”, Sci Adv, 8(14): p. eabn7105 2022. https://doi.org/10.1126/sciadv.abn7105
Efstathiou, S., Ottens, F., Schutter, L.S., Ravanelli, S., Charmpilas, N., Gutschmidt, A., Le Pen, J., Gehring, N.H., Miska, E.A., Boucas, J., and Hoppe, T., “ER-associated RNA silencing promotes ER quality control”, Nat Cell Biol, 24(12): p. 1714-1725 2022. https://doi.org/10.1038/s41556-022-01025-4
Hoehne, M.N., Jacobs, L., Lapacz, K.J., Calabrese, G., Murschall, L.M., Marker, T., Kaul, H., Trifunovic, A., Morgan, B., Fricker, M., Belousov, V.V., and Riemer, J., “Spatial and temporal control of mitochondrial H(2) O(2) release in intact human cells”, EMBO J, 41(7): p. e109169 2022. https://doi.org/10.15252/embj.2021109169
Hommen, F., Bilican, S., and Vilchez, D., “Protein clearance strategies for disease intervention”, J Neural Transm (Vienna), 129(2): p. 141-172 2022. https://doi.org/10.1007/s00702-021-02431-y
Huang, W., Kew, C., Fernandes, S.d.A., Löhrke, A., Han, L., Demetriades, C., and Antebi, A., “Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity”, Nature Aging, 2(9): p. 796-808 2022. https://doi.org/10.1038/s43587-022-00275-z
Huth, M., Santini, L., Galimberti, E., Ramesmayer, J., Titz-Teixeira, F., Sehlke, R., Oberhuemer, M., Stummer, S., Herzog, V., Garmhausen, M., Romeike, M., Chugunova, A., Leesch, F., Holcik, L., Weipoltshammer, K., Lackner, A., Schoefer, C., von Haeseler, A., Buecker, C., Pauli, A., Ameres, S.L., Smith, A., Beyer, A., and Leeb, M., “NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation”, Genes Dev, 36(5-6): p. 348-367 2022. https://doi.org/10.1101/gad.347690.120
Imai, T., Van, T.M., Pasparakis, M., and Polykratis, A., “Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE(-/-) mice”, Sci Rep, 12(1): p. 12538 2022. https://doi.org/10.1038/s41598-022-16737-8
Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., and Denzel, M.S., “GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway”, Elife, 11: p. e69223 2022. https://doi.org/10.7554/eLife.69223
Kulshammer, E., Kilinc, M., Csordas, G., Bresser, T., Nolte, H., and Uhlirova, M., “The mechanosensor Filamin A/Cheerio promotes tumourigenesis via specific interactions with components of the cell cortex”, FEBS J, 289(15): p. 4497-4517 2022. https://doi.org/10.1111/febs.16408
Leote, A.C., Wu, X., and Beyer, A., “Regulatory network-based imputation of dropouts in single-cell RNA sequencing data”, PLoS Comput Biol, 18(2): p. e1009849 2022. https://doi.org/10.1371/journal.pcbi.1009849
Li, X., Straub, J., Medeiros, T.C., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Adrain, C., Munch, C., Riemer, J., Becker, T., and Pernas, L.F., “Mitochondria shed their outer membrane in response to infection-induced stress”, Science, 375(6577): p. eabi4343 2022. https://doi.org/10.1126/science.abi4343
Longarini, E.J. and Matic, I., “The fast-growing business of Serine ADP-ribosylation”, DNA Repair (Amst), 118: p. 103382 2022. https://doi.org/10.1016/j.dnarep.2022.103382
Miranda, M., Bonekamp, N.A., and Kuhl, I., “Starting the engine of the powerhouse: mitochondrial transcription and beyond”, Biol Chem, 403(8-9): p. 779-805 2022. https://doi.org/10.1515/hsz-2021-0416
Ratz, L., Brambillasca, C., Bartke, L., Huetzen, M. A., Goergens, J., Leidecker, O., Jachimowicz, R. D., van de Ven, M., Proost, N., Siteur, B., de Korte-Grimmerink, R., Bouwman, P., Pulver, E. M., de Bruijn, R., Isensee, J., Hucho, T., Pandey, G., van Lohuizen, M., Mallmann, P., Reinhardt, H. C., Jonkers, J., and Puppe, J., “Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer”, Breast Cancer Res, 24(1),p. 41, 2022. https://doi.org/10.1186/s13058-022-01534-y
Segref, A., Vakkayil, K.L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Korner, L., Finger, F., and Hoppe, T., “Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling”, Nat Commun, 13(1): p. 5874 2022. https://doi.org/10.1038/s41467-022-33467-7
Vaddavalli, P.L. and Schumacher, B., “The p53 network: cellular and systemic DNA damage responses in cancer and aging”, Trends Genet, 38(6): p. 598-612 2022. https://doi.org/10.1016/j.tig.2022.02.010
Vakkayil, K.L. and Hoppe, T., “Temperature-Dependent Regulation of Proteostasis and Longevity”, Front Aging, 3: p. 853588 2022. https://doi.org/10.3389/fragi.2022.853588
Vesting, A.J., Jais, A., Klemm, P., Steuernagel, L., Wienand, P., Fog-Tonnesen, M., Hvid, H., Schumacher, A.L., Kukat, C., Nolte, H., Georgomanolis, T., Altmuller, J., Pasparakis, M., Schmidt, A., Kruger, M., Supprian, M.S., Waisman, A., Straub, B.K., Raschzok, N., Bernier, M., Birkenfeld, A.L., Hovelmeyer, N., Bruning, J.C., and Wunderlich, F.T., “NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition”, Mol Metab, 66: p. 101626 2022. https://doi.org/10.1016/j.molmet.2022.101626
Wani, G.A., Sprenger, H.G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Muller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., and Bergami, M., “Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L”, Cell Rep, 38(7): p. 110370 2022. https://doi.org/10.1016/j.celrep.2022.110370
Zhang, W.H., Koyuncu, S., and Vilchez, D., “Insights Into the Links Between Proteostasis and Aging From C. elegans”, Front Aging, 3: p. 854157 2022. https://doi.org/10.3389/fragi.2022.854157
2021
Allmeroth, K. and Denzel, M.S., “The RATIOnal Role of Polyamines in Epidermal Differentiation”, J Invest Dermatol, 141(9): p. 2105-2107 2021. https://doi.org/10.1016/j.jid.2021.02.011
Allmeroth, K., Horn, M., Kroef, V., Miethe, S., Muller, R.U., and Denzel, M.S., “Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma”, Leukemia, 35(3): p. 887-892 2021. https://doi.org/10.1038/s41375-020-0989-4
Allmeroth, K., Kim, C.S., Annibal, A., Pouikli, A., Koester, J., Derisbourg, M.J., Andres Chacon-Martinez, C., Latza, C., Antebi, A., Tessarz, P., Wickstrom, S.A., and Denzel, M.S., “N1-acetylspermidine is a determinant of hair follicle stem cell fate”, J Cell Sci, 134(9): p. jcs252767 2021. https://doi.org/10.1242/jcs.252767
Annibal, A., Ripa, R., Ballhysa, E., Latza, C., Hochhard, N., and Antebi, A., “Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo”, Anal Bioanal Chem, 413(26): p. 6457-6468 2021. https://doi.org/10.1007/s00216-021-03628-6
Atilano, M.L., Gronke, S., Niccoli, T., Kempthorne, L., Hahn, O., Moron-Oset, J., Hendrich, O., Dyson, M., Adams, M.L., Hull, A., Salcher-Konrad, M.T., Monaghan, A., Bictash, M., Glaria, I., Isaacs, A.M., and Partridge, L., “Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila”, Elife, 10: p. e58565 2021. https://doi.org/10.7554/eLife.58565
Beckert, V., Rassmann, S., Kayvanjoo, A.H., Klausen, C., Bonaguro, L., Botermann, D.S., Krause, M., Moreth, K., Spielmann, N., da Silva-Buttkus, P., Fuchs, H., Gailus-Durner, V., de Angelis, M.H., Handler, K., Ulas, T., Aschenbrenner, A.C., Mass, E., and Wachten, D., “Creld1 regulates myocardial development and function”, J Mol Cell Cardiol, 156: p. 45-56 2021. https://doi.org/10.1016/j.yjmcc.2021.03.008
Calculli, G., Lee, H.J., Shen, K., Pham, U., Herholz, M., Trifunovic, A., Dillin, A., and Vilchez, D., “Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans”, Sci Adv, 7(26): p. eabg3012 2021. https://doi.org/10.1126/sciadv.abg3012
da Silva, P.F.L. and Schumacher, B., “Principles of the Molecular and Cellular Mechanisms of Aging”, J Invest Dermatol, 141(4S): p. 951-960 2021. https://doi.org/10.1016/j.jid.2020.11.018
Derisbourg, M.J., Wester, L.E., Baddi, R., and Denzel, M.S., “Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation”, Nat Commun, 12(1): p. 1678 2021. https://doi.org/10.1038/s41467-021-21743-x
Erkelenz, S., Stankovic, D., Mundorf, J., Bresser, T., Claudius, A.K., Boehm, V., Gehring, N.H., and Uhlirova, M., “Ecd promotes U5 snRNP maturation and Prp8 stability”, Nucleic Acids Res, 49(3): p. 1688-1707 2021. https://doi.org/10.1093/nar/gkaa1274
Fernandes, S.A. and Demetriades, C., “The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging”, Front Aging, 2: p. 707372 2021. https://doi.org/10.3389/fragi.2021.707372
Gouveia, A., de Oliveira Beleza, R., and Steculorum, S.M., “AgRP neuronal activity across feeding-related behaviours”, Eur J Neurosci, 54(10): p. 7458-7475 2021. https://doi.org/10.1111/ejn.15498
Guerrero, G.A., Derisbourg, M.J., Mayr, F.A., Wester, L.E., Giorda, M., Dinort, J.E., Hartman, M.D., Schilling, K., Alonso-De Gennaro, M.J., Lu, R.J., Benayoun, B.A., and Denzel, M.S., “NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants”, Elife, 10: p. e53174 2021. https://doi.org/10.7554/eLife.53174
Kaspar, S., Oertlin, C., Szczepanowska, K., Kukat, A., Senft, K., Lucas, C., Brodesser, S., Hatzoglou, M., Larsson, O., Topisirovic, I., and Trifunovic, A., “Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR”, Sci Adv, 7(22): p. eabf0971 2021. https://doi.org/10.1126/sciadv.abf0971
Kochan, D.Z., Mawer, J.S.P., Massen, J., Tishinov, K., Parekh, S., Graef, M., Spang, A., and Tessarz, P., “The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription”, J Cell Sci, 134(15) 2021. https://doi.org/10.1242/jcs.259051
Koyuncu, S., Loureiro, R., Lee, H.J., Wagle, P., Krueger, M., and Vilchez, D., “Rewiring of the ubiquitinated proteome determines ageing in C. elegans”, Nature, 596(7871): p. 285-290 2021. https://doi.org/10.1038/s41586-021-03781-z
Kumari, S., Van, T.M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., and Pasparakis, M., “NF-kappaB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation”, Life Sci Alliance, 4(6): p. e202000956 2021. https://doi.org/10.26508/lsa.202000956
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Medeiros, T.C., Mehra, C., and Pernas, L., “Contact and competition between mitochondria and microbes”, Curr Opin Microbiol, 63: p. 189-194 2021. https://doi.org/10.1016/j.mib.2021.07.014
Mehra, C. and Pernas, L., “Move it to lose it: Mitocytosis expels damaged mitochondria”, Dev Cell, 56(14): p. 2014-2015 2021. https://doi.org/10.1016/j.devcel.2021.07.001
Meyer, D.H. and Schumacher, B., “BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy”, Aging Cell, 20(3): p. e13320 2021. https://doi.org/10.1111/acel.13320
Muller, L., Kutzner, C.E., Balaji, V., and Hoppe, T., “In Vitro Analysis of E3 Ubiquitin Ligase Function”, J Vis Exp, (171): p. e62393 2021. https://doi.org/10.3791/62393
Pouikli, A., Parekh, S., Maleszewska, M., Nikopoulou, C., Baghdadi, M., Tripodi, I., Folz-Donahue, K., Hinze, Y., Mesaros, A., Hoey, D., Giavalisco, P., Dowell, R., Partridge, L., and Tessarz, P., “Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells”, Nature Aging, 1(9): p. 810-825 2021. https://doi.org/10.1038/s43587-021-00105-8
Schiffer, I., Gerisch, B., Kawamura, K., Laboy, R., Hewitt, J., Denzel, M.S., Mori, M.A., Vanapalli, S., Shen, Y., Symmons, O., and Antebi, A., “miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging”, eLife, 10: p. e66768 2021. https://doi.org/10.7554/eLife.66768
Sprenger, H.G., MacVicar, T., Bahat, A., Fiedler, K.U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N., Larsson, N.G., Nolte, H., Giavalisco, P., and Langer, T., “Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity”, Nat Metab, 3(5): p. 636-650 2021. https://doi.org/10.1038/s42255-021-00385-9
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2020
Balaji, V. and Hoppe, T., “Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly”, F1000Res, 9: p. F1000 Faculty Rev-88 2020. https://doi.org/10.12688/f1000research.21253.1
Bayer, E.A., Stecky, R.C., Neal, L., Katsamba, P.S., Ahlsen, G., Balaji, V., Hoppe, T., Shapiro, L., Oren-Suissa, M., and Hobert, O., “Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior”, Elife, 9: p. e59614 2020. https://doi.org/10.7554/eLife.59614
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Bradshaw, W.J. and Valenzano, D.R., “Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes”, Proc Biol Sci, 287(1927): p. 20200489 2020. https://doi.org/10.1098/rspb.2020.0489
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Gerisch, B., Tharyan, R.G., Mak, J., Denzel, S.I., Popkes-van Oepen, T., Henn, N., and Antebi, A., “HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence”, Dev Cell, 53(3): p. 316-329 e5 2020. https://doi.org/10.1016/j.devcel.2020.03.014
Hansen, J.N., Kaiser, F., Klausen, C., Stuven, B., Chong, R., Bonigk, W., Mick, D.U., Moglich, A., Jurisch-Yaksi, N., Schmidt, F.I., and Wachten, D., “Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium”, Elife, 9: p. e57907 2020. https://doi.org/10.7554/eLife.57907
Horn, M., Denzel, S.I., Srinivasan, B., Allmeroth, K., Schiffer, I., Karthikaisamy, V., Miethe, S., Breuer, P., Antebi, A., and Denzel, M.S., “Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response”, iScience, 23(3): p. 100887 2020. https://doi.org/10.1016/j.isci.2020.100887
Hos, N.J., Fischer, J., Hos, D., Hejazi, Z., Calabrese, C., Ganesan, R., Murthy, A.M.V., Rybniker, J., Kumar, S., Kronke, M., and Robinson, N., “TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection”, J Immunol, 205(9): p. 2456-2467 2020. https://doi.org/10.4049/jimmunol.2000048
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Kim, C.S., D. Xiaolei, K. Allmeroth, M.S. Denzel, S. A. Eming, S. A. Wickström, "Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle", Cell Matabolism,2020 Sep 8,https://doi.org/10.1016/j.cmet.2020.08.011
Llamas, E., Alirzayeva, H., Loureiro, R., and Vilchez, D., “The intrinsic proteostasis network of stem cells”, Curr Opin Cell Biol, 67: p. 46-55 2020. https://doi.org/10.1016/j.ceb.2020.08.005
Mittenbuhler, M.J., Saedler, K., Nolte, H., Kern, L., Zhou, J., Qian, S.B., Meder, L., Ullrich, R.T., Bruning, J.C., and Wunderlich, F.T., “Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo”, Mol Metab, 42: p. 101085 2020. https://doi.org/10.1016/j.molmet.2020.101085
Meyer, D. H., B. Schumacher, "A transcriptome based aging clock near the theoretical limit of accuracy", bioRxiv, 31 May 2020, https://doi.org/10.1101/2020.05.29.123430
Motori, E., Atanassov, I., Kochan, S.M.V., Folz-Donahue, K., Sakthivelu, V., Giavalisco, P., Toni, N., Puyal, J., and Larsson, N.G., “Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction”, Sci Adv, 6(35): p. eaba8271 2020. https://doi.org/10.1126/sciadv.aba8271
Pradas-Juni, M., Hansmeier, N.R., Link, J.C., Schmidt, E., Larsen, B.D., Klemm, P., Meola, N., Topel, H., Loureiro, R., Dhaouadi, I., Kiefer, C.A., Schwarzer, R., Khani, S., Oliverio, M., Awazawa, M., Frommolt, P., Heeren, J., Scheja, L., Heine, M., Dieterich, C., Buning, H., Yang, L., Cao, H., Jesus, D.F., Kulkarni, R.N., Zevnik, B., Troder, S.E., Knippschild, U., Edwards, P.A., Lee, R.G., Yamamoto, M., Ulitsky, I., Fernandez-Rebollo, E., Vallim, T.Q.A., and Kornfeld, J.W., “A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism”, Nat Commun, 11(1): p. 644 2020. https://doi.org/10.1038/s41467-020-14323-y
Ruegenberg, S., Horn, M., Pichlo, C., Allmeroth, K., Baumann, U., and Denzel, M.S., “Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis”, Nat Commun, 11(1): p. 687 2020. https://doi.org/10.1038/s41467-020-14524-5
Stankovic, D., Claudius, A.K., Schertel, T., Bresser, T., and Uhlirova, M., “A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8”, Dis Model Mech, 13(6): p. dmm043174 2020. https://doi.org/10.1242/dmm.043174
Schiffer, I. B. Gerisch, K. Kawamura, R. Laboy, J. Hewitt, M. S. Denzel, M. A. Mori, S. Vanapalli, Y. Shen, O. Symmons, A. Antebi, "miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing" (preprint), doi: https://doi.org/10.1101/2021.01.21.427623
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2019
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Fischer, J., Gutierrez, S., Ganesan, R., Calabrese, C., Ranjan, R., Cildir, G., Hos, N.J., Rybniker, J., Wolke, M., Fries, J.W.U., Tergaonkar, V., Plum, G., Antebi, A., and Robinson, N., “Leptin signaling impairs macrophage defenses against Salmonella Typhimurium”, Proc Natl Acad Sci U S A, 116(33): p. 16551-16560 2019.
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Jachimowicz, R.D., Beleggia, F., Isensee, J., Velpula, B.B., Goergens, J., Bustos, M.A., Doll, M.A., Shenoy, A., Checa-Rodriguez, C., Wiederstein, J.L., Baranes-Bachar, K., Bartenhagen, C., Hertwig, F., Teper, N., Nishi, T., Schmitt, A., Distelmaier, F., Ludecke, H.J., Albrecht, B., Kruger, M., Schumacher, B., Geiger, T., Hoon, D.S.B., Huertas, P., Fischer, M., Hucho, T., Peifer, M., Ziv, Y., Reinhardt, H.C., Wieczorek, D., and Shiloh, Y., “UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors”, Cell, 176(3): p. 505-519 e22 2019.
Jiang, S., Koolmeister, C., Misic, J., Siira, S., Kuhl, I., Silva Ramos, E., Miranda, M., Jiang, M., Posse, V., Lytovchenko, O., Atanassov, I., Schober, F.A., Wibom, R., Hultenby, K., Milenkovic, D., Gustafsson, C.M., Filipovska, A., and Larsson, N.G., “TEFM regulates both transcription elongation and RNA processing in mitochondria”, EMBO Rep, 20(6): p. e48101 2019.
Klausen, C., Kaiser, F., Stuven, B., Hansen, J.N., and Wachten, D., “Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors”, Biochem Soc Trans, 47(6): p. 1733-1747 2019.
Lausch, M., M. Bartusel, R. Rehimi, H. Alirzayeva, A. Karaolidou, G. Crispatzu, P. Zentis, M. Nikolic, T. Bleckwehl, P. Kolovos, W. FJ van Ijcken, T. Šarić, K. Koehler, P. Frommolt, K. Lachlan, J. Baptista, A. Rada-Iglesias, “Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs”. Cell Stem Cell. 2019 May 2; 24(5): 736-752.
Lee, H.J., Noormohammadi, A., Koyuncu, S., Calculli, G., Simic, M.S., Herholz, M., Trifunovic, A., and Vilchez, D., “Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans”, Nat Metab, 1(8): p. 790-810 2019.
MacVicar, T., Ohba, Y., Nolte, H., Mayer, F.C., Tatsuta, T., Sprenger, H.G., Lindner, B., Zhao, Y., Li, J., Bruns, C., Kruger, M., Habich, M., Riemer, J., Schwarzer, R., Pasparakis, M., Henschke, S., Bruning, J.C., Zamboni, N., and Langer, T., “Lipid signalling drives proteolytic rewiring of mitochondria by YME1L”, Nature, 575(7782): p. 361-365 2019.
Medeiros, T.C. and Graef, M., “Autophagy determines mtDNA copy number dynamics during starvation”, Autophagy, 15(1): p. 178-179 2019.
Morón-Oset, J., T. Supèr, J. Esser et al., "Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain". Acta neuropathol commun, 7, 209 (2019).
Ostermann, A.L., Wunderlich, C.M., Schneiders, L., Vogt, M.C., Woeste, M.A., Belgardt, B.F., Niessen, C.M., Martiny, B., Schauss, A.C., Frommolt, P., Nikolaev, A., Hovelmeyer, N., Sears, R.C., Koch, P.J., Gunzel, D., Bruning, J.C., and Wunderlich, F.T., “Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer”, Nat Metab, 1(3): p. 371-389 2019.
Ribeiro Jr. A.F., L.S. Souza, C.F. Almeida, R. Ishiba, S.A. Fernandes, D.A. Guerrieri, A.L.F. Santos, P.C.G Onofre-Oliveira, M. Vainzo, "Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies", Aug 14, 9:11842, Scientific Reports, 2019.
Saez, I., Gerbracht, J.V., Koyuncu, S., Lee, H.J., Horn, M., Kroef, V., Denzel, M.S., Dieterich, C., Gehring, N.H., and Vilchez, D., “The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells”, FEBS Lett, 594(1): p. 175-188 2019.
Silva Ramos, E., Motori, E., Bruser, C., Kuhl, I., Yeroslaviz, A., Ruzzenente, B., Kauppila, J.H.K., Busch, J.D., Hultenby, K., Habermann, B.H., Jakobs, S., Larsson, N.G., and Mourier, A., “Mitochondrial fusion is required for regulation of mitochondrial DNA replication”, PLoS Genet, 15(6): p. e1008085 2019.
Sprenger, H.G. and Langer, T., “The Good and the Bad of Mitochondrial Breakups”, Trends Cell Biol, 29(11): p. 888-900 2019.
Sprenger, H.G., Wani, G., Hesseling, A., Konig, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., and Langer, T., “Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy”, EMBO Mol Med, 11(1) 2019.
2018
Bacman, S.R., Kauppila, J.H.K., Pereira, C.V., Nissanka, N., Miranda, M., Pinto, M., Williams, S.L., Larsson, N.G., Stewart, J.B., and Moraes, C.T., “MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation”, Nat Med, 24(11): p. 1696-1700 2018.
Balaji, V., W. Pokrzywa, and T. Hoppe, “Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis,” BioEssays, vol. 1700223, pp. 1–10, 2018.
Brandt, C., Nolte, H., Henschke, S., Engstrom Ruud, L., Awazawa, M., Morgan, D.A., Gabel, P., Sprenger, H.G., Hess, M.E., Gunther, S., Langer, T., Rahmouni, K., Fenselau, H., Kruger, M., and Bruning, J.C., “Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation”, Cell, 175(5): p. 1321-1335 e20 2018.
de Vrij, F. M., C. G. Bouwkamp, N. Gunhanlar, G. Shpak, B. Lendemeijer, M. Baghdadi, S. Gopalakrishna, M. Ghazvini, T. M. Li, M. Quadri, S. Olgiati, G. J. Breedveld, M. Coesmans, E. Mientjes, T. de Wit, F. W. Verheijen, H. B. Beverloo, D. Cohen, R. M. Kok, P. R. Bakker, A. Nijburg, A. T. Spijker, P. M. J. Haffmans, E. Hoencamp, V. Bergink, J. A. Vorstman, T. Wu, L. M. Olde Loohuis, N. Amin, C. D. Langen, A. Hofman, W. J. Hoogendijk, C. M. van Duijn, M. A. Ikram, M. W. Vernooij, H. Tiemeier, A. G. Uitterlinden, Y. Elgersma, B. Distel, J. Gribnau, T. White, V. Bonifati, and S. A. Kushner, “Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia,” Molecular Psychiatry, pp. 1–15, 2018.
Debès, C., Leote, A.C., and Beyer, A., “Computational approaches for the systematic analysis of aging-associated molecular alterations”, Drug Discovery Today: Disease Models, 27: p. 51-59 2018.
Gupta, R., Somyajit, K., Narita, T., Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, N., Nussenzweig, A., Lukas, J., and Choudhary, C., “DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity”, Cell, 173(4): p. 972-988 e23 2018.
Horn, M., Kroef, V., Allmeroth, K., Schuller, N., Miethe, S., Peifer, M., Penninger, J.M., Elling, U., and Denzel, M.S., “Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells”, Oncotarget, 9(11): p. 9838-9851 2018.
Kern, L., M. J. Mittenbühler, A. J. Vesting, A. L. Ostermann, C. M. Wunderlich, F. T. Wunderlich, “Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers”, Cancers, 2018.
Kremer, M., Kuhlmann, N., Lechner, M., Baldus, L., and Lammers, M., “Comment on 'YcgC represents a new protein deacetylase family in prokaryotes'”, Elife, 7: p. e37798 2018.
Koyuncu, S., Saez, I., Lee, H.J., Gutierrez-Garcia, R., Pokrzywa, W., Fatima, A., Hoppe, T., and Vilchez, D., “The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients”, Nat Commun, 9(1): p. 2886 2018.
Medeiros, T. C., R. L. Thomas, R. Ghillebert, and M. Graef, “Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation.,” J. Cell Biol., p. jcb.201801168, 2018.
Mittenbühler, M.J., H-G Sprenger, S. Gruber, C. M. Wunderlich, L. Kern, J. C. Brüning, F. T. Wunderlich, “Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma”, Mol. Met., 2018.
Noormohammadi, A., Calculli, G., Gutierrez-Garcia, R., Khodakarami, A., Koyuncu, S., and Vilchez, D., “Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells”, Cell Mol Life Sci, 75(2): p. 275-290 2018.
Ou, H.-L. and B. Schumacher, “DNA damage responses and p53 in the aging process,” Blood, vol. 131, no. 5, pp. 488–495, 2018.
Patron, M., H.-G. Sprenger, and T. Langer, “m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration,” Cell Res., vol. 28, no. 3, pp. 296–306, 2018.
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Saez, I., S. Koyuncu, R. Gutierrez-Garcia, C. Dieterich, and D. Vilchez, “Insights into the ubiquitin-proteasome system of human embryonic stem cells,” Sci. Rep., vol. 8, no. 1, 2018.
Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N.R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P., Orom, U.A., Heeren, J., Bluher, M., Bilban, M., and Kornfeld, J.W., “LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat”, Nat Commun, 9(1): p. 3622 2018.
Welcker, D.*, M. Jain*, S. Khurshid*, M. Jokić, M. Höhne, A. Schmitt, P. Frommolt, C. M. Niessen, J. Spiro, T. Persigehl, M. Wittersheim, R. Büttner, M. Fanciulli, B. Schermer, H. C. Reinhardt, T. Benzing, and K. Höpker, “AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer,” Oncogene, vol. 37, no. 11, pp. 1503–1518, 2018.
Wunderlich, C.M., Ackermann, P.J., Ostermann, A.L., Adams-Quack, P., Vogt, M.C., Tran, M.L., Nikolajev, A., Waisman, A., Garbers, C., Theurich, S., Mauer, J., Hovelmeyer, N., and Wunderlich, F.T., “Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment”, Nat Commun, 9(1): p. 1646 2018.
2017
Amin, N., F. De Vrij, M. Baghdadi, R. Brouwer, J. Van Rooij, O. Jovanova, A. Uitterlinden, A. Hofman, H. Janssen, S. D. Murad, R. Kraaij, J. Stedehouder, M. Van Den Hout, J. Kros, W. Van Ijcken, H. Tiemeier, S. Kushner, and C. Van Duijn, “A rare missense variant in RCL1 segregates with depression in extended families,” Molec. Psych., vol. 21, no. 10, pp. 1–7, 2017.
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Ganesan, R., N. J. Hos, S. Gutierrez, J. Fischer, N. Robinson, M. Stepek, E. Daglidu, and M. Kro, “Salmonella Typhimurium disrupts Sirt1 / AMPK checkpoint control of mTOR to impair autophagy,” PLOS Pathog., 13(2), pp. 1–22, 2017.
Ibn-Salem, J., S. Meiers, O. Eigenbrod, R. Sehlke, S. Talyan, K. Schwan, R. Otto, A. Pataskar, F. Metge, and P. Angerer, “Highlights of the 1st Student Symposium on Computational Genomics,” Genomics Comput. Biol., vol. 2, no. 1, p. e59, 2017.
Koyuncu, S., A. Fatima, R. Gutierrez-Garcia, and D. Vilchez, “Proteostasis of huntingtin in health and disease,” International Journal of Molecular Sciences, vol. 18, no. 7. 2017.
Kohli P, Höhne M, Jungst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B, The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep 18(9):1521-1535, 2017. doi: 10.15252/embr.201643846
Kühl, I.*, M. Miranda*, I. Atanassov, I. Kuznetsova, Y. Hinze, A. Mourier, A. Filipovska, and N. G. Larsson, “Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals,” Elife, vol. 6, 2017.
Liu, H.*, J. A. Dowdle*, S. Khurshid*, N. J. Sullivan, N. Bertos, K. Rambani, M. Mair, P. Daniel, E. Wheeler, X. Tang, K. Toth, M. Lause, M. E. Harrigan, K. Eiring, C. Sullivan, M. J. Sullivan, S. W. Chang, S. Srivastava, J. S. Conway, R. Kladney, J. McElroy, S. Bae, Y. Lu, A. Tofigh, S. M. I. Saleh, S. A. Fernandez, J. D. Parvin, V. Coppola, E. R. Macrae, S. Majumder, C. L. Shapiro, L. D. Yee, B. Ramaswamy, M. Hallett, M. C. Ostrowski, M. Park, H. M. Chamberlin, and G. Leone, “Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation,” Dev. Cell, vol. 41, no. 4, p. 392–407.e6, 2017.
López-Noriega, L., N. Cobo-Vuilleumier, Á. J. Narbona-Pérez, J. L. Araujo-Garrido, P. I. Lorenzo, J. M. Mellado-Gil, J. C. Moreno, B. R. Gauthier, A. Martín-Montalvo, "Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice", Br J Pharmacol, 2017.
Moosa, S., H. Böhrer-Rabel, J. Altmüller, F. Beleggia, P. Nürnberg, Y. Li, G. Yigit, and B. Wollnik, “Smith-Kingsmore syndrome: A third family with the MTOR mutation c.5395G>A p.(Glu1799Lys) and evidence for paternal gonadal mosaicism,” Am. J. Med. Genet. Part A, vol. 173, no. 1, pp. 264–267, 2017.
Rinschen, M. M., F. Grahammer, A. Hoppe, P. Kohli, H. Hagmann, O. Kretz, S. Bertsch, M. Höhne, H. Göbel, M. P. Bartram, R. K. Gandhirajan, M. Krüger, P. Brinkkoetter, T. B. Huber, M. Kann, and S. A. Wickström, “YAP-mediated mechanotransduction determines the podocyte ’ s response to damage,” Sci Signal., vol. 8165, no. April, pp. 1–16, 2017.
Tain, L. S.*, R. Sehlke*, C. Jain, M. Chokkalingam, N. Nagaraj, P. Essers, M. Rassner, S. Grönke, J. Froelich, C. Dieterich, M. Mann, N. Alic, A. Beyer, and L. Partridge, “A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance,” Mol. Syst. Biol., vol. 13, no. 9, p. 939, 2017.
Tawo, R., W. Pokrzywa, E. Kevei, M. E. Akyuz, V. Balaji, S. Adrian, J. Höhfeld, and T. Hoppe, “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover,” Cell, vol. 169, pp. 470–482, 2017.
Van, T.-M., A. Polykratis, B. K. Straub, V. Kondylis, N. Papadopoulou, and M. Pasparakis, “Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis,” J. Clin. Invest., vol. 127, no. 7, pp. 2662–2677, 2017.
Weir, H. J., P. Yao, F. K. Huynh, C. C. Escoubas, R. L. Goncalves, K. Burkewitz, R. Laboy, M. D. Hirschey, and W. B. Mair, “Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling,” Cell Metab., vol. 26, no. 6, p. 884–896.e5, 2017.
2016
Aguilar-Lopez, J. L., R. Laboy, F. Jaimes-Miranda, E. Garay, A. DeLuna, and S. Funes, “Slm35 links mitochondrial stress response and longevity through TOR signaling pathway,” Aging (Albany. NY)., vol. 8, no. 12, pp. 3255–3271, 2016.
Burnouf, S., S. Grönke, H. Augustin, J. Dols, M. K. Gorsky, J. Werner, F. Kerr, N. Alic, P. Martinez, and L. Partridge, “Deletion of endogenous Tau proteins is not detrimental in Drosophila.,” Sci. Rep., vol. 6, no. February, p. 23102, 2016.
Bögershausen, N., U. Altunoglu, F. Beleggia, G. Yigit, H. Kayserili, P. Nürnberg, Y. Li, J. Altmüller, and B. Wollnik, “An unusual presentation of Kabuki syndrome with orbital cysts, microphthalmia, and cholestasis with bile duct paucity,” Am. J. Med. Genet. Part A, vol. 170, no. 12, pp. 3282–3288, 2016.
Cacciola, N. A., C. Calabrese, U. Malapelle, G. Pellino, A. De Stefano, R. Sepe, R. Sgariglia, C. Quintavalle, A. Federico, A. Bianco, A. Uchimura Bastos, M. Milone, C. Bellevicine, F. Milone, C. Carlomagno, F. Selvaggi, G. Troncone, A. Fusco, and P. Pallante, “UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients,” Mol. Carcinog., vol. 55, no. 5, pp. 793–807, 2016.
Cimen, I., B. Kocaturk, S. Koyuncu, O. Tufanl , U. I. Onat, A. D. Y ld r m, O. Apayd n, eyma Demirsoy, Z. G. Aykut, U. T. Nguyen, S. M. Watkins, G. S. Hotam l gil, and E. Erbay, “Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation,” Sci. Transl. Med., vol. 8, no. 358, p. 358ra126-358ra126, 2016.
Glenewinkel, F., M. J. Cohen, C. R. King, S. Kaspar, S. Bamberg-Lemper, J. S. Mymryk, and W. Becker, “The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2,” Sci. Rep., vol. 6, no. 1, p. 28241, 2016.
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Guelinckx, I., G. Tavoularis, J. König, C. Morin, H. Gharbi, and J. Gandy, “Contribution of water from food and fluids to total water intake: Analysis of a French and UK population surveys,” Nutrients, vol. 8, no. 10, 2016.
Hatzold, J., F. Beleggia, H. Herzig, J. Altmüller, P. Nürnberg, W. Bloch, B. Wollnik, and M. Hammerschmidt, “Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit,” Elife, vol. 5, no. MAY2016, 2016.
Kochan, D. Z. and O. Kovalchuk, “Circadian disruption-induced breast cancer - knowns and unknowns,” Cell Cycle, vol. 15, no. 5. pp. 613–614, 2016.
Kochan, D. Z., Y. Ilnytskyy, A. Golubov, S. H. Deibel, R. J. McDonald, and O. Kovalchuk, “Circadian-disruption-induced gene expression changes in rodent mammary tissues.,” Oncoscience, vol. 3, no. 2, pp. 58–70, 2016.
Koehler, S., S. Brähler, A. Kuczkowski, J. Binz, M. J. Hackl, H. Hagmann, M. Höhne, M. C. Vogt, C. M. Wunderlich, F. T. Wunderlich, F. Schweda, B. Schermer, T. Benzing, and P. T. Brinkkoetter, “Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.,” Sci. Rep., vol. 6, p. 35400, 2016.
Korwitz, A., C. Merkwirth, R. Richter-Dennerlein, S. E. Tröder, H. G. Sprenger, P. M. Quirós, C. López-Otín, E. I. Rugarli, and T. Langer, “Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria,” J. Cell Biol., vol. 212, no. 2, pp. 157–166, 2016.
König, T., S. E. Tröder, K. Bakka, A. Korwitz, R. Richter-Dennerlein, P. A. Lampe, M. Patron, M. Mühlmeister, S. Guerrero-Castillo, U. Brandt, T. Decker, I. Lauria, A. Paggio, R. Rizzuto, E. I. Rugarli, D. De Stefani, and T. Langer, “The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria,” Mol. Cell, vol. 64, no. 1, pp. 148–162, 2016.
Kühl, I., M. Miranda, V. Posse, D. Milenkovic, A. Mourier, S. J. Siira, N. A. Bonekamp, U. Neumann, A. Filipovska, P. L. Polosa, C. M. Gustafsson, and N.-G. Larsson, “POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.,” Sci. Adv., vol. 2, no. 8, p. e1600963, 2016.
Kühn, A. B., D. L. Feis, L. Schilbach, L. Kracht, M. E. Hess, J. Mauer, J. C. Brüning, and M. Tittgemeyer, “FTO gene variant modulates the neural correlates of visual food perception,” Neuroimage, vol. 128, pp. 21–31, 2016.
Lal, D., B. A. Neubauer, M. R. Toliat, J. Altmöller, H. Thiele, P. Nörnberg, C. Kamrath, A. Schänzer, T. Sander, A. Hahn, and M. Nothnagel, “Increased probability of co-occurrence of two rare diseases in consanguineous families and resolution of a complex phenotype by next generation sequencing,” PLoS One, vol. 11, no. 1, 2016.
Lal, D., E. M. Reinthaler, B. Dejanovic, P. May, H. Thiele, A. E. Lehesjoki, G. Schwarz, E. Riesch, M. A. Ikram, C. M. Van Duijn, A. G. Uitterlinden, A. Hofman, H. Steinböck, U. Gruber-Sedlmayr, B. Neophytou, F. Zara, A. Hahn, P. Gormley, F. Becker, Y. G. Weber, M. R. Cilio, W. S. Kunz, R. Krause, F. Zimprich, J. R. Lemke, P. Nürnberg, T. Sander, H. Lerche, et al., “Evaluation of presumably disease causing SCN1A variants in a cohort of common epilepsy syndromes,” PLoS One, vol. 11, no. 3, 2016.
Lemke, J. R., K. Geider, K. L. Helbig, H. O. Heyne, H. Schütz, J. Hentschel, C. Courage, C. Depienne, C. Nava, D. Heron, R. S. Møller, H. Hjalgrim, D. Lal, B. A. Neubauer, P. Nürnberg, H. Thiele, G. Kurlemann, G. L. Arnold, V. Bhambhani, D. Bartholdi, C. R. J. Pedurupillay, D. Misceo, E. Frengen, P. Strømme, D. J. Dlugos, E. S. Doherty, E. K. Bijlsma, et al., “Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy,” Neurology, vol. 86, no. 23, pp. 2171–2178, 2016.
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Lotan, Y., J. Antonelli, I. B. Jiménez, H. Gharbi, R. Herring, A. Beaver, A. Dennis, D. von Merveldt, S. Carter, A. Cohen, J. Poindexter, O. W. Moe, and M. S. Pearle, “The kidney stone and increased water intake trial in steel workers: results from a pilot study,” Urolithiasis, pp. 1–7, 2016.
Manjunath, G. P., N. Soni, P. L. Vaddavalli, D. J. Shewale, M. S. Madhusudhan, and K. Muniyappa, “Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA,” Biochemistry, vol. 55, no. 12, pp. 1850–1862, 2016.
Naranjo, J. R., H. Zhang, D. Villar, P. González, X. M. Dopazo, J. Morón-Oset, E. Higueras, J. C. Oliveros, M. D. Arrabal, A. Prieto, P. Cercós, T. González, A. De La Cruz, J. Casado-Vela, A. Rábano, C. Valenzuela, M. Gutierrez-Rodriguez, J. Y. Li, and B. Mellström, “Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease,” J. Clin. Invest., vol. 126, no. 2, pp. 627–638, 2016.
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Noormohammadi, A., A. Khodakarami, R. Gutierrez-Garcia, H. J. Lee, S. Koyuncu, T. König, C. Schindler, I. Saez, A. Fatima, C. Dieterich, and D. Vilchez, “Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan,” Nat. Commun., vol. 7, p. 13649, 2016.
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2015
Beleggia, F., Y. Li, J. Fan, N. H. Elcioglu, E. Toker, T. Wieland, I. H. Maumenee, N. A. Akarsu, T. Meitinger, T. M. Strom, R. Lang, and B. Wollnik, “CRIM1 haploinsufficiency causes defects in eye development in human and mouse,” Hum. Mol. Genet., vol. 24, no. 8, pp. 2267–2273, 2015.
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2014
Dejanovic, B., D. Lal, C. B. Catarino, S. Arjune, A. A. Belaidi, H. Trucks, C. Vollmar, R. Surges, W. S. Kunz, S. Motameny, J. Altmüller, A. Köhler, B. A. Neubauer, EPICURE Consortium, P. Nürnberg, S. Noachtar, G. Schwarz, and T. Sander, “Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy,” Neurobiol. Dis., vol. 67, pp. 88–96, 2014.
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Parameswaran, R., M. Lim, F. Fei, H. Abdel-Azim, A. Arutyunyan, I. Schiffer, M. E. McLaughlin, H. Gram, H. Huet, J. Groffen, and N. Heisterkamp, “Effector-Mediated Eradication of Precursor B Acute Lymphoblastic Leukemia with a Novel Fc-Engineered Monoclonal Antibody Targeting the BAFF-R,” Mol. Cancer Ther., vol. 13, no. 6, pp. 1567–1577, 2014.
Pérez-Rodríguez, R., A. M. Oliván, C. Roncero, J. Morón-Oset, M. P. González, and M. J. Oset-Gasque, “Glutamate triggers neurosecretion and apoptosis in bovine chromaffin cells through a mechanism involving NO production by neuronal NO synthase activation,” Free Radic. Biol. Med., vol. 69, pp. 390–402, 2014.
Pichlo, M., S. Bungert-Plümke, I. Weyand, R. Seifert, W. Bönigk, T. Strünker, N. D. Kashikar, N. Goodwin, A. Müller, P. Pelzer, Q. Van, J. Enderlein, C. Klemm, E. Krause, C. Trötschel, A. Poetsch, E. Kremmer, U. B. Kaupp, H. G. Körschen, and U. Collienne, “High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor,” J. Cell Biol., vol. 206, no. 4, pp. 541–557, 2014.
Polykratis, A., N. Hermance, M. Zelic, J. Roderick, C. Kim, T. M. Van, T. H. Lee, F. K. Chan, M. Pasparakis, and M. A. Kelliher, “RIPK1 kinase inactive mice are viable and protected from TNF- induced necroptosis in vivo,” J Immunol., vol. 193(4), pp. 1539–1543, 2014.
Reinthaler, E. M., D. Lal, W. Jurkowski, M. Feucht, H. Steinböck, U. Gruber-Sedlmayr, G. M. Ronen, J. Geldner, E. Haberlandt, B. Neophytou, A. Hahn, J. Altmüller, H. Thiele, M. R. Toliat, H. Lerche, P. Nürnberg, T. Sander, B. A. Neubauer, and F. Zimprich, “Analysis of ELP4, SRPX2, and interacting genes in typical and atypical rolandic epilepsy,” Epilepsia, vol. 55, no. 8, 2014.
Reinthaler, E. M., D. Lal, S. Lebon, M. S. Hildebrand, H. H. M. Dahl, B. M. Regan, M. Feucht, H. Steinböck, B. Neophytou, G. M. Ronen, L. Roche, U. Gruber-Sedlmayr, J. Geldner, E. Haberlandt, P. Hoffmann, S. Herms, C. Gieger, M. Waldenberger, A. Franke, M. Wittig, S. Schoch, A. J. Becker, A. Hahn, K. Männik, M. R. Toliat, G. Winterer, H. Lerche, P. Nürnberg, H. Mefford, I. E. Scheffer, S. F. Berkovic, J. S. Beckmann, T. Sander, S. Jacquemont, A. Reymond, F. Zimprich, and B. A. Neubauer, “16p11.2 600 kb duplications confer risk for typical and atypical rolandic epilepsy,” Hum. Mol. Genet., vol. 23, no. 22, pp. 6069–6080, 2014.
Rinschen, M. M., X. Wu, T. König, T. Pisitkun, H. Hagmann, C. Pahmeyer, T. Lamkemeyer, P. Kohli, N. Schnell, B. Schermer, S. Dryer, B. R. Brooks, P. Beltrao, M. Krueger, P. T. Brinkkoetter, and T. Benzing, “Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration Barrier.,” J. Am. Soc. Nephrol., vol. 25, no. 7, pp. 1509–1522, 2014.
Schreml, J., B. Durmaz, O. Cogulu, K. Keupp, F. Beleggia, E. Pohl, E. Milz, M. Coker, S. K. Ucar, G. Nürnberg, P. Nürnberg, J. Kuhn, and F. Ozkinay, “The missing ‘link’: An autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation,” Hum. Genet., vol. 133, no. 1, pp. 29–39, 2014
Teixeira, V., T. C. Medeiros, R. Vilaça, P. Moradas-ferreira, and V. Costa, “Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells,” Microb. Cell, vol. 1, no. 1, pp. 21–36, 2014.
Tellkamp, F., S. Vorhagen, and C. M. Niessen, “Epidermal polarity genes in health and disease,” Cold Spring Harb. Perspect. Med., vol. 4, no. 12, 2014.
Tellkamp, F., F. Benhadou, J. Bremer, M. Gnarra, J. Knüver, S. Schaffenrath, and S. Vorhagen, “Transgenic Mouse Technology in Skin Biology: Generation of Knockin Mice,” J. Invest. Dermatol., vol. 134, no. 12, p. e27, 2014.
Tsaousidou, E., L. Paeger, B. F. Belgardt, M. Pal, C. M. Wunderlich, H. Brönneke, U. Collienne, B. Hampel, F. T. Wunderlich, M. Schmidt-Supprian, P. Kloppenburg, and J. C. Brüning, “Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance,” Cell Rep., vol. 9, no. 4, pp. 1495–1506, 2014.
Vogt, M. C., L. Paeger, S. Hess, S. M. Steculorum, M. Awazawa, B. Hampel, S. Neupert, H. T. Nicholls, J. Mauer, A. C. Hausen, R. Predel, P. Kloppenburg, T. L. Horvath, and J. C. Brüning, “Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding,” Cell, vol. 156, no. 3, pp. 495–509, 2014.
2013
Demirci, S., E. Koban Baştanlar, N. D. Dağtaş, E. Pişkin, A. Engin, F. Ozer, E. Yüncü, S. A. Doğan, and I. Togan, “Mitochondrial DNA diversity of modern, ancient and wild sheep(Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep.,” PLoS One, vol. 8, no. 12, p. e81952, 2013.
Ermolaeva, M. A., A. Segref, A. Dakhovnik, H.-L. Ou, J. I. Schneider, O. Utermöhlen, T. Hoppe, and B. Schumacher, “DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.,” Nature, vol. 501, no. 7467, pp. 416–420, 2013.
Frank, V., S. Habbig, M. P. Bartram, T. Eisenberger, H. E. Veenstra-Knol, C. Decker, R. A. C. Boorsma, H. Göbel, G. Nürnberg, A. Griessmann, M. Franke, L. Borgal, P. Kohli, L. A. Völker, J. Dötsch, P. Nürnberg, T. Benzing, H. J. Bolz, C. Johnson, E. H. Gerkes, B. Schermer, and C. Bergmann, “Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression,” Hum. Mol. Genet., vol. 22, no. 11, pp. 2177–2185, 2013.
Gharbi, H., F. Fabretti, P. Bharill, M. M. Rinschen, S. Brinkkötter, P. Frommolt, V. Burst, B. Schermer, T. Benzing, and R. U. Müller, “Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner,” Aging Cell, vol. 12, no. 4, pp. 593–603, 2013.
Hess, M.E., S. Hess, K. D. Meyer, L. a W. Verhagen, L. Koch, H. S. Brönneke, M. O. Dietrich, S. D. Jordan, Y. Saletore, O. Elemento, B. F. Belgardt, T. Franz, T. L. Horvath, U. Rüther, S. R. Jaffrey, P. Kloppenburg, and J. C. Brüning, “The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.,” Nat. Neurosci., vol. 16, no. 8, pp. 1042–8, 2013.
Karra, E., O. G. O’Daly, A. I. Choudhury, A. Yousseif, S. Millership, M. T. Neary, W. R. Scott, K. Chandarana, S. Manning, M. E. Hess, H. Iwakura, T. Akamizu, Q. Millet, C. Gelegen, M. E. Drew, S. Rahman, J. J. Emmanuel, S. C. R. Williams, U. U. Rüther, J. C. Brüning, D. J. Withers, F. O. Zelaya, and R. L. Batterham, “A link between FTO, ghrelin, and impaired brain food-cue responsivity,” J. Clin. Invest., vol. 123, no. 8, pp. 3539–3551, 2013.
Keupp, K., F. Beleggia, H. Kayserili, A. M. Barnes, M. Steiner, O. Semler, B. Fischer, G. Yigit, C. Y. Janda, J. Becker, S. Breer, U. Altunoglu, J. Grünhagen, P. Krawitz, J. Hecht, T. Schinke, E. Makareeva, E. Lausch, T. Cankaya, J. A. Caparrós-Martín, P. Lapunzina, S. Temtamy, M. Aglan, B. Zabel, P. Eysel, F. Koerber, S. Leikin, K. C. Garcia, C. Netzer, E. Schönau, V. L. Ruiz-Perez, S. Mundlos, M. Amling, U. Kornak, J. Marini, and B. Wollnik, “Mutations in WNT1 cause different forms of bone fragility,” Am. J. Hum. Genet., vol. 92, no. 4, pp. 565–574, 2013.
Kornfeld, J.-W., C. Baitzel, a C. Könner, H. T. Nicholls, M. C. Vogt, K. Herrmanns, L. Scheja, C. Haumaitre, A. M. Wolf, U. Knippschild, J. Seibler, S. Cereghini, J. Heeren, M. Stoffel, and J. C. Brüning, “Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.,” Nature, vol. 494, no. 7435, pp. 111–5, 2013.
Lal, D., H. Trucks, R. S. Møller, H. Hjalgrim, B. P. C. Koeleman, C. G. F. De Kovel, F. Visscher, Y. G. Weber, H. Lerche, F. Becker, C. J. Schankin, B. A. Neubauer, R. Surges, W. S. Kunz, F. Zimprich, A. Franke, T. Illig, J. S. Ried, C. Leu, P. Nürnberg, T. Sander, et al., “Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy,” Epilepsia, vol. 54, no. 2, pp. 265–271, 2013.
Lal, D., K. Becker, S. Motameny, J. Altmüller, H. Thiele, P. Nürnberg, U. Ahting, B. Rolinski, B. A. Neubauer, and A. Hahn, “Homozygous missense mutation of NDUFV1 as the cause of infantile bilateral striatal necrosis,” Neurogenetics, vol. 14, no. 1. pp. 85–87, 2013.
Lal, D., E. M. Reinthaler, J. Altmüller, M. R. Toliat, H. Thiele, P. Nürnberg, H. Lerche, A. Hahn, R. S. Møller, H. Muhle, T. Sander, F. Zimprich, and B. A. Neubauer, “RBFOX1 and RBFOX3 Mutations in Rolandic Epilepsy,” PLoS One, vol. 8, no. 9, 2013.
Lemke, J. R., D. Lal, E. M. Reinthaler, I. Steiner, M. Nothnagel, M. Alber, K. Geider, B. Laube, M. Schwake, K. Finsterwalder, A. Franke, M. Schilhabel, J. A. Jähn, H. Muhle, R. Boor, W. Van Paesschen, R. Caraballo, N. Fejerman, S. Weckhuysen, P. De Jonghe, J. Larsen, R. S. Møller, H. Hjalgrim, L. Addis, S. Tang, E. Hughes, D. K. Pal, K. Veri, U. Vaher, T. Talvik, P. Dimova, et al., “Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.,” Nat. Genet., vol. 45, no. 9, pp. 1067–72, 2013.
Mullen, S. A., G. L. Carvill, S. Bellows, M. A. Bayly, H. Trucks, D. Lal, T. Sander, S. F. Berkovic, L. M. Dibbens, I. E. Scheffer, and C. Mefford, H, “Copy number variants are frequent in genetic generalized epilepsy with intellectual disability,” Neurology, vol. 81, no. 17, pp. 1507–1514, 2013.
Müller, R., C. Herr, S. K. Sukumaran, N. N. Omosigho, M. Plomann, T. Y. Riyahi, M. Stumpf, K. Swaminathan, M. Tsangarides, K. Yiannakou, R. Blau-Wasser, C. Gallinger, M. Schleicher, W. Kolanus, and A. a Noegel, “The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.,” Cell Commun. Signal., vol. 11, p. 54, 2013.
Newton, A. J., S. Hess, L. Paeger, M. C. Vogt, J. F. Lascano, E. A. Nillni, J. C. Brüning, P. Kloppenburg, and A. W. Xu, “AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice,” Endocrinology, vol. 154, no. 1, pp. 172–183, 2013.
Niessen, M. T., J. Scott, J. G. Zielinski, S. Vorhagen, P. A. Sotiropoulou, C. Blanpain, M. Leitges, and C. M. Niessen, “Apkcγ controls epidermal homeostasis and stemcell fate through regulation of division orientation,” J. Cell Biol., vol. 202, no. 6, pp. 887–900, 2013.
Pohl, E., A. Aykut, F. Beleggia, E. Karaca, B. Durmaz, K. Keupp, E. Arslan, M. P. Onay, G. Yigit, F. Özkinay, and B. Wollnik, “A hypofunctional PAX1 mutation causes autosomal recessively inherited otofaciocervical syndrome,” Hum. Genet., vol. 132, no. 11, pp. 1311–1320, 2013.
Potting, C., T. Tatsuta, T. König, M. Haag, T. Wai, M. J. Aaltonen, and T. Langer, “TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid,” Cell Metab., vol. 18, no. 2, pp. 287–295, 2013.
Rossi, M., S. Duan, Y. T. Jeong, M. Horn, A. Saraf, L. Florens, M. P. Washburn, A. Antebi, and M. Pagano, “Regulation of the CRL4Cdt2 ubiquitin ligase and Cell-Cycle exit by the SCFFbxo11 ubiquitin ligase,” Mol. Cell, vol. 49, no. 6, pp. 1159–1166, 2013.
Steculorum, S. M., M. C. Vogt, and J. C. Brüning, “Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits,” Endocrinology and Metabolism Clinics of North America, vol. 42, no. 1. pp. 149–164, 2013.
Vogt, M. C. and J. C. Brüning, “CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age,” Trends Endocrinol. Metab., vol. 24, no. 2, pp. 76–84, 2013.
Wieczorek, D., N. Bögershausen, F. Beleggia, S. Steiner-Haldenstätt, E. Pohl, Y. Li, E. Milz, M. Martin, H. Thiele, J. Altmüller, Y. Alanay, H. Kayserili, L. Klein-Hitpass, S. Böhringer, A. Wollstein, B. Albrecht, K. Boduroglu, A. Caliebe, K. Chrzanowska, O. Cogulu, F. Cristofoli, J. C. Czeschik, K. Devriendt, M. T. Dotti, N. Elcioglu, B. Gener, T. O. Goecke, M. Krajewska-Walasek, , et al., “A comprehensive molecular study on coffin-siris and nicolaides-baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling,” Hum. Mol. Genet., vol. 22, no. 25, pp. 5121–5135, 2013.
Yüncü, E., S. Demirci, E. Koban Baştanlar, Ş. A. Doǧan, U. Taşdemir, and N. Togan, “Comparative study of three simple molecular approaches in search of mtDNA haplogroup identification of domestic sheep,” Small Rumin. Res., vol. 114, no. 1, pp. 64–71, 2013.
2012
Thier, M., P. Wörsdörfer, Y. B. Lakes, R. Gorris, S. Herms, T. Opitz, D. Seiferling, T. Quandel, P. Hoffmann, M. M. Nöthen, O. Brüstle, and F. Edenhofer, “Direct conversion of fibroblasts into stably expandable neural stem cells,” Cell Stem Cell, vol. 10, no. 4, pp. 473–479, 2012.
Zeller, E., K. Mock, M. Horn, S. Colnot, M. Schwarz, and A. Braeuning, “Dual-specifi city phosphatases are targets of the Wnt/β-catenin pathway and candidate mediators of β-catenin/Ras signaling interactions,” Biol. Chem., vol. 393, no. 10, pp. 1183–1191, 2012.
2011
Dogan, S. A. and A. Trifunovic, “Modelling mitochondrial dysfunction in mice.,” Physiol. Res., vol. 60 Suppl 1, pp. S61-70, 2011.
Hou, Y. Y., H. L. Ou, S. T. Chu, P. C. Wu, P. J. Lu, C. C. Chi, K. W. Leung, C. Y. Lee, P. H. Wu, M. Hsiao, and L. P. Ger, “NAT2 slow acetylation haplotypes are associated with the increased risk of betel quidrelated oral and pharyngeal squamous cell carcinoma,” Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology, vol. 112, no. 4, pp. 484–492, 2011.
Kukat, A., D. Edgar, I. Bratic, P. Maiti, and A. Trifunovic, “Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts,” Biochem. Biophys. Res. Commun., vol. 409, no. 3, pp. 394–399, 2011.
Yabas, M., C. E. Teh, S. Frankenreiter, D. Lal, C. M. Roots, B. Whittle, D. T. Andrews, Y. Zhang, N. C. Teoh, J. Sprent, E. Tze, E. M. Kucharska, J. Kofler, G. C. Farell, and S. Bröer, “ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation,” Nat Immunol., vol. 12, no. 5, pp. 441–449, 2011.
2010
Kruttwig, K., C. Brueggemann, E. Kaijzel, S. Vorhagen, T. Hilger, C. Löwik, and M. Hoehn, “Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: monitoring by magnetic resonance imaging and optical imaging.,” Mol. imaging Biol., vol. 12, no. 4, pp. 367–76, 2010.
Wu, Y.-L., Y. R. Kou, H.-L. Ou, H.-Y. Chien, K.-H. Chuang, H.-H. Liu, T.-S. Lee, C.-Y. Tsai, and M.-L. Lu, “Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells,” Eur. J. Pharmacol., vol. 635, no. 1–3, pp. 219–226, 2010.
2009
Follmann, M., I. Ochrombel, R. Krämer, C. Trötschel, A. Poetsch, C. Rückert, A. Hüser, M. Persicke, D. Seiferling, J. Kalinowski, and K. Marin, “Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis.,” BMCGenomics, vol. 10, p. 621, 2009.