Averdunk, L., Huetzen, M.A., Moreno-Andres, D., Kalb, R., McKee, S., Hsieh, T.C., Seibt, A., Schouwink, M., Lalani, S., Faqeih, E.A., Brunet, T., Boor, P., Neveling, K., Hoischen, A., Hildebrandt, B., Graf, E., Lu, L., Jin, W., Schaper, J., Omer, J.A., Demaret, T., Fleischer, N., Schindler, D., Krawitz, P., Mayatepek, E., Wieczorek, D., Wang, L.L., Antonin, W., Jachimowicz, R.D., von Felbert, V., and Distelmaier, F., “Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence”, Genet Med: p. 100836 2023. https://doi.org/10.1016/j.gim.2023.100836

Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D.J., Gronke, S., and Partridge, L., “Reduced insulin signaling in neurons induces sex-specific health benefits”, Sci Adv,  9(8): p. eade8137 2023. https://doi.org/10.1126/sciadv.ade8137

Bujarrabal-Dueso, A., Sendtner, G., Meyer, D.H., Chatzinikolaou, G., Stratigi, K., Garinis, G.A., and Schumacher, B., “The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities”, Nat Struct Mol Biol,  2023. https://doi.org/10.1038/s41594-023-00942-8

Deshwal, S., Onishi, M., Tatsuta, T., Bartsch, T., Cors, E., Ried, K., Lemke, K., Nolte, H., Giavalisco, P., and Langer, T., “Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7”, Nat Cell Biol,  25(2): p. 246-257 2023. https://doi.org/10.1038/s41556-022-01071-y

Dolfi, L., Ripa, R., Medelbekova, D., Ballhysa, E., Symmons, O., and Antebi, A., “Nonlethal Blood Sampling from the Killifish Nothobranchius furzeri”, Cold Spring Harb Protoc,  2023. https://doi.org/10.1101/pdb.prot107745

Flumann, R., Hansen, J., Pelzer, B.W., Nieper, P., Lohmann, T., Kisis, I., Riet, T., Kohlhas, V., Nguyen, P.H., Peifer, M., Abedpour, N., Bosco, G., Thomas, R.K., Kochanek, M., Knufer, J., Jonigkeit, L., Beleggia, F., Holzem, A., Buttner, R., Lohneis, P., Meinel, J., Ortmann, M., Persigehl, T., Hallek, M., Calado, D.P., Chmielewski, M., Klein, S., Gothert, J.R., Chapuy, B., Zevnik, B., Wunderlich, F.T., von Tresckow, B., Jachimowicz, R.D., Melnick, A.M., Reinhardt, H.C., and Knittel, G., “Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies”, Blood Cancer Discov,  4(1): p. 78-97 2023. https://doi.org/10.1158/2643-3230.BCD-22-0007

Gutierrez-Garcia, R., Koyuncu, S., Hommen, F., Bilican, S., Lee, H.J., Fatima, A., and Vilchez, D., “G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly”, Hum Mol Genet,  2023. https://doi.org/10.1093/hmg/ddac304

Hagmann, H., Khayyat, N.H., Matin, M., Oezel, C., Chen, H., Schauss, A., Schell, C., Benzing, T., Dryer, S., and Brinkkoetter, P.T., “Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy”, Cells,  12(2): p. 271 2023. https://doi.org/10.3390/cells12020271

Johns, A., Higuchi-Sanabria, R., Thorwald, M.A., and Vilchez, D., “A tale of two pathways: Regulation of proteostasis by UPR(mt) and MDPs”, Curr Opin Neurobiol,  78: p. 102673 2023. https://doi.org/10.1016/j.conb.2022.102673

Lee, H.J., Alirzayeva, H., Koyuncu, S., Rueber, A., Noormohammadi, A., and Vilchez, D., “Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes”, Nature Aging,  2023. https://doi.org/10.1038/s43587-023-00383-4

Muller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernandez, L., Bragelmann, J., Leprivier, G., and von Karstedt, S., “Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation”, Cell Death Differ,  30(2): p. 442-456 2023. https://doi.org/10.1038/s41418-022-01096-8

Ripa, R., Mesaros, A., Symmons, O., Ballhysa, E., Dolfi, L., and Antebi, A., “Micro-CT Analysis of Fat in the Killifish Nothobranchius furzeri”, Cold Spring Harb Protoc,  2023. https://doi.org/10.1101/pdb.prot107884

Rivera-Mejias, P., Narbona-Perez, A.J., Hasberg, L., Kroczek, L., Bahat, A., Lawo, S., Folz-Donahue, K., Schumacher, A.L., Ahola, S., Mayer, F.C., Giavalisco, P., Nolte, H., Lavandero, S., and Langer, T., “The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage”, Cell Rep,  42(4): p. 112332 2023. https://doi.org/10.1016/j.celrep.2023.112332

Rozsivalova, D.H., Popovic, M., Kaul, H., and Trifunovic, A., “Isolation of Functional Mitochondria and Pure mtDNA from Murine Tissues”, Methods Mol Biol,  2615: p. 3-16 2023. https://doi.org/10.1007/978-1-0716-2922-2_1

Seidel, J., Bradshaw, W.J., and Valenzano, D.R., “Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish (Nothobranchius furzeri)”, Cold Spring Harb Protoc,  2023. https://doi.org/10.1101/pdb.prot107750

Selle, J., Bohl, K., Hopker, K., Wilke, R., Dinger, K., Kasper, P., Abend, B., Schermer, B., Muller, R.U., Kurschat, C., Nusken, K.D., Nusken, E., Meyer, D., Savai Pullamsetti, S., Schumacher, B., Dotsch, J., and Alcazar, M.A.A., “Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling”, Int J Mol Sci,  24(3): p. 2508 2023. https://doi.org/10.3390/ijms24032508

Stankovic, D., Csordas, G., and Uhlirova, M., “Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes”, Life Sci Alliance,  6(2): p. e202201801 2023. https://doi.org/10.26508/lsa.202201801

Steiner, J.D., Annibal, A., Laboy, R., Braumann, M., Gobel, H., Laasch, V., Muller, R.U., Spath, M.R., Antebi, A., and Kubacki, T., “A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature”, Rheumatology (Oxford): p. kead068 2023. https://doi.org/10.1093/rheumatology/kead068

Wang, S., Meyer, D.H., and Schumacher, B., “Inheritance of paternal DNA damage by histone-mediated repair restriction”, Nature,  613(7943): p. 365-374 2023. https://doi.org/10.1038/s41586-022-05544-w

Wester, L.E., Lanjuin, A., Bruckisch, E.H.W., Perez-Matos, M.C., Stine, P.G., Heintz, C., Denzel, M.S., and Mair, W.B., “A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans”, Cell Rep Methods,  3(3): p. 100433 2023. https://doi.org/10.1016/j.crmeth.2023.100433


Allmeroth, K., Hartman, M.D., Purrio, M., Mesaros, A., and Denzel, M.S., “Hexosamine pathway activation improves memory but does not extend lifespan in mice”, Aging Cell,  21(10): p. e13711 2022. https://doi.org/10.1111/acel.13711

Baghdadi, M., Hinterding, H.M., Partridge, L., and Deelen, J., “From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing”, Brief Funct Genomics,  21(1): p. 13-23 2022. https://doi.org/10.1093/bfgp/elab005

Balaji, V., Muller, L., Lorenz, R., Kevei, E., Zhang, W.H., Santiago, U., Gebauer, J., Llamas, E., Vilchez, D., Camacho, C.J., Pokrzywa, W., and Hoppe, T., “A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing”, Mol Cell,  82(17): p. 3239-3254 e11 2022. https://doi.org/10.1016/j.molcel.2022.08.003

Bozukova, M., Nikopoulou, C., Kleinenkuhnen, N., Grbavac, D., Goetsch, K., and Tessarz, P., “Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver”, Mol Syst Biol,  18(9): p. e11002 2022. https://doi.org/10.15252/msb.202211002

Bradshaw, W.J., Poeschla, M., Placzek, A., Kean, S., and Valenzano, D.R., “Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish”, Elife,  11: p. e65117 2022. https://doi.org/10.7554/eLife.65117

Croon, M., Szczepanowska, K., Popovic, M., Lienkamp, C., Senft, K., Brandscheid, C.P., Bock, T., Gnatzy-Feik, L., Ashurov, A., Acton, R.J., Kaul, H., Pujol, C., Rosenkranz, S., Kruger, M., and Trifunovic, A., “FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction”, Sci Adv,  8(14): p. eabn7105 2022. https://doi.org/10.1126/sciadv.abn7105

Efstathiou, S., Ottens, F., Schutter, L.S., Ravanelli, S., Charmpilas, N., Gutschmidt, A., Le Pen, J., Gehring, N.H., Miska, E.A., Boucas, J., and Hoppe, T., “ER-associated RNA silencing promotes ER quality control”, Nat Cell Biol,  24(12): p. 1714-1725 2022. https://doi.org/10.1038/s41556-022-01025-4

Hoehne, M.N., Jacobs, L., Lapacz, K.J., Calabrese, G., Murschall, L.M., Marker, T., Kaul, H., Trifunovic, A., Morgan, B., Fricker, M., Belousov, V.V., and Riemer, J., “Spatial and temporal control of mitochondrial H(2) O(2) release in intact human cells”, EMBO J,  41(7): p. e109169 2022. https://doi.org/10.15252/embj.2021109169

Hommen, F., Bilican, S., and Vilchez, D., “Protein clearance strategies for disease intervention”, J Neural Transm (Vienna),  129(2): p. 141-172 2022. https://doi.org/10.1007/s00702-021-02431-y

Huang, W., Kew, C., Fernandes, S.d.A., Löhrke, A., Han, L., Demetriades, C., and Antebi, A., “Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity”, Nature Aging,  2(9): p. 796-808 2022. https://doi.org/10.1038/s43587-022-00275-z

Huth, M., Santini, L., Galimberti, E., Ramesmayer, J., Titz-Teixeira, F., Sehlke, R., Oberhuemer, M., Stummer, S., Herzog, V., Garmhausen, M., Romeike, M., Chugunova, A., Leesch, F., Holcik, L., Weipoltshammer, K., Lackner, A., Schoefer, C., von Haeseler, A., Buecker, C., Pauli, A., Ameres, S.L., Smith, A., Beyer, A., and Leeb, M., “NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation”, Genes Dev,  36(5-6): p. 348-367 2022. https://doi.org/10.1101/gad.347690.120

Imai, T., Van, T.M., Pasparakis, M., and Polykratis, A., “Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE(-/-) mice”, Sci Rep,  12(1): p. 12538 2022. https://doi.org/10.1038/s41598-022-16737-8

Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., and Denzel, M.S., “GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway”, Elife,  11: p. e69223 2022. https://doi.org/10.7554/eLife.69223

Kulshammer, E., Kilinc, M., Csordas, G., Bresser, T., Nolte, H., and Uhlirova, M., “The mechanosensor Filamin A/Cheerio promotes tumourigenesis via specific interactions with components of the cell cortex”, FEBS J,  289(15): p. 4497-4517 2022. https://doi.org/10.1111/febs.16408

Leote, A.C., Wu, X., and Beyer, A., “Regulatory network-based imputation of dropouts in single-cell RNA sequencing data”, PLoS Comput Biol,  18(2): p. e1009849 2022. https://doi.org/10.1371/journal.pcbi.1009849

Li, X., Straub, J., Medeiros, T.C., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Adrain, C., Munch, C., Riemer, J., Becker, T., and Pernas, L.F., “Mitochondria shed their outer membrane in response to infection-induced stress”, Science,  375(6577): p. eabi4343 2022. https://doi.org/10.1126/science.abi4343

Longarini, E.J. and Matic, I., “The fast-growing business of Serine ADP-ribosylation”, DNA Repair (Amst),  118: p. 103382 2022. https://doi.org/10.1016/j.dnarep.2022.103382

Miranda, M., Bonekamp, N.A., and Kuhl, I., “Starting the engine of the powerhouse: mitochondrial transcription and beyond”, Biol Chem,  403(8-9): p. 779-805 2022. https://doi.org/10.1515/hsz-2021-0416

Segref, A., Vakkayil, K.L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Korner, L., Finger, F., and Hoppe, T., “Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling”, Nat Commun,  13(1): p. 5874 2022. https://doi.org/10.1038/s41467-022-33467-7

Vaddavalli, P.L. and Schumacher, B., “The p53 network: cellular and systemic DNA damage responses in cancer and aging”, Trends Genet,  38(6): p. 598-612 2022. https://doi.org/10.1016/j.tig.2022.02.010

Vakkayil, K.L. and Hoppe, T., “Temperature-Dependent Regulation of Proteostasis and Longevity”, Front Aging,  3: p. 853588 2022. https://doi.org/10.3389/fragi.2022.853588

Vesting, A.J., Jais, A., Klemm, P., Steuernagel, L., Wienand, P., Fog-Tonnesen, M., Hvid, H., Schumacher, A.L., Kukat, C., Nolte, H., Georgomanolis, T., Altmuller, J., Pasparakis, M., Schmidt, A., Kruger, M., Supprian, M.S., Waisman, A., Straub, B.K., Raschzok, N., Bernier, M., Birkenfeld, A.L., Hovelmeyer, N., Bruning, J.C., and Wunderlich, F.T., “NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition”, Mol Metab,  66: p. 101626 2022. https://doi.org/10.1016/j.molmet.2022.101626

Wani, G.A., Sprenger, H.G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Muller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., and Bergami, M., “Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L”, Cell Rep,  38(7): p. 110370 2022. https://doi.org/10.1016/j.celrep.2022.110370

Zhang, W.H., Koyuncu, S., and Vilchez, D., “Insights Into the Links Between Proteostasis and Aging From C. elegans”, Front Aging, 3: p. 854157 2022. https://doi.org/10.3389/fragi.2022.854157


Allmeroth, K. and Denzel, M.S., “The RATIOnal Role of Polyamines in Epidermal Differentiation”, J Invest Dermatol,  141(9): p. 2105-2107 2021. https://doi.org/10.1016/j.jid.2021.02.011

Allmeroth, K., Horn, M., Kroef, V., Miethe, S., Muller, R.U., and Denzel, M.S., “Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma”, Leukemia,  35(3): p. 887-892 2021. https://doi.org/10.1038/s41375-020-0989-4

Allmeroth, K., Kim, C.S., Annibal, A., Pouikli, A., Koester, J., Derisbourg, M.J., Andres Chacon-Martinez, C., Latza, C., Antebi, A., Tessarz, P., Wickstrom, S.A., and Denzel, M.S., “N1-acetylspermidine is a determinant of hair follicle stem cell fate”, J Cell Sci,  134(9): p. jcs252767 2021. https://doi.org/10.1242/jcs.252767

Annibal, A., Ripa, R., Ballhysa, E., Latza, C., Hochhard, N., and Antebi, A., “Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo”, Anal Bioanal Chem,  413(26): p. 6457-6468 2021. https://doi.org/10.1007/s00216-021-03628-6

Atilano, M.L., Gronke, S., Niccoli, T., Kempthorne, L., Hahn, O., Moron-Oset, J., Hendrich, O., Dyson, M., Adams, M.L., Hull, A., Salcher-Konrad, M.T., Monaghan, A., Bictash, M., Glaria, I., Isaacs, A.M., and Partridge, L., “Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila”, Elife,  10: p. e58565 2021. https://doi.org/10.7554/eLife.58565

Beckert, V., Rassmann, S., Kayvanjoo, A.H., Klausen, C., Bonaguro, L., Botermann, D.S., Krause, M., Moreth, K., Spielmann, N., da Silva-Buttkus, P., Fuchs, H., Gailus-Durner, V., de Angelis, M.H., Handler, K., Ulas, T., Aschenbrenner, A.C., Mass, E., and Wachten, D., “Creld1 regulates myocardial development and function”, J Mol Cell Cardiol,  156: p. 45-56 2021. https://doi.org/10.1016/j.yjmcc.2021.03.008

Calculli, G., Lee, H.J., Shen, K., Pham, U., Herholz, M., Trifunovic, A., Dillin, A., and Vilchez, D., “Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans”, Sci Adv,  7(26): p. eabg3012 2021. https://doi.org/10.1126/sciadv.abg3012

da Silva, P.F.L. and Schumacher, B., “Principles of the Molecular and Cellular Mechanisms of Aging”, J Invest Dermatol,  141(4S): p. 951-960 2021. https://doi.org/10.1016/j.jid.2020.11.018

Derisbourg, M.J., Wester, L.E., Baddi, R., and Denzel, M.S., “Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation”, Nat Commun,  12(1): p. 1678 2021. https://doi.org/10.1038/s41467-021-21743-x

Erkelenz, S., Stankovic, D., Mundorf, J., Bresser, T., Claudius, A.K., Boehm, V., Gehring, N.H., and Uhlirova, M., “Ecd promotes U5 snRNP maturation and Prp8 stability”, Nucleic Acids Res,  49(3): p. 1688-1707 2021. https://doi.org/10.1093/nar/gkaa1274

Fernandes, S.A. and Demetriades, C., “The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging”, Front Aging,  2: p. 707372 2021. https://doi.org/10.3389/fragi.2021.707372

Gouveia, A., de Oliveira Beleza, R., and Steculorum, S.M., “AgRP neuronal activity across feeding-related behaviours”, Eur J Neurosci,  54(10): p. 7458-7475 2021. https://doi.org/10.1111/ejn.15498

Guerrero, G.A., Derisbourg, M.J., Mayr, F.A., Wester, L.E., Giorda, M., Dinort, J.E., Hartman, M.D., Schilling, K., Alonso-De Gennaro, M.J., Lu, R.J., Benayoun, B.A., and Denzel, M.S., “NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants”, Elife,  10: p. e53174 2021. https://doi.org/10.7554/eLife.53174

Kaspar, S., Oertlin, C., Szczepanowska, K., Kukat, A., Senft, K., Lucas, C., Brodesser, S., Hatzoglou, M., Larsson, O., Topisirovic, I., and Trifunovic, A., “Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR”, Sci Adv,  7(22): p. eabf0971 2021. https://doi.org/10.1126/sciadv.abf0971

Kochan, D.Z., Mawer, J.S.P., Massen, J., Tishinov, K., Parekh, S., Graef, M., Spang, A., and Tessarz, P., “The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription”, J Cell Sci,  134(15) 2021. https://doi.org/10.1242/jcs.259051

Koyuncu, S., Loureiro, R., Lee, H.J., Wagle, P., Krueger, M., and Vilchez, D., “Rewiring of the ubiquitinated proteome determines ageing in C. elegans”, Nature,  596(7871): p. 285-290 2021. https://doi.org/10.1038/s41586-021-03781-z

Kumari, S., Van, T.M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., and Pasparakis, M., “NF-kappaB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation”, Life Sci Alliance,  4(6): p. e202000956 2021. https://doi.org/10.26508/lsa.202000956

Lackner, A., Sehlke, R., Garmhausen, M., Giuseppe Stirparo, G., Huth, M., Titz-Teixeira, F., van der Lelij, P., Ramesmayer, J., Thomas, H.F., Ralser, M., Santini, L., Galimberti, E., Sarov, M., Stewart, A.F., Smith, A., Beyer, A., and Leeb, M., “Cooperative genetic networks drive embryonic stem cell transition from naive to formative pluripotency”, EMBO J,  40(8): p. e105776 2021. https://doi.org/10.15252/embj.2020105776

Medeiros, T.C., Mehra, C., and Pernas, L., “Contact and competition between mitochondria and microbes”, Curr Opin Microbiol,  63: p. 189-194 2021. https://doi.org/10.1016/j.mib.2021.07.014

Mehra, C. and Pernas, L., “Move it to lose it: Mitocytosis expels damaged mitochondria”, Dev Cell,  56(14): p. 2014-2015 2021. https://doi.org/10.1016/j.devcel.2021.07.001

Meyer, D.H. and Schumacher, B., “BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy”, Aging Cell,  20(3): p. e13320 2021. https://doi.org/10.1111/acel.13320

Muller, L., Kutzner, C.E., Balaji, V., and Hoppe, T., “In Vitro Analysis of E3 Ubiquitin Ligase Function”, J Vis Exp, (171): p. e62393 2021. https://doi.org/10.3791/62393

Pouikli, A., Parekh, S., Maleszewska, M., Nikopoulou, C., Baghdadi, M., Tripodi, I., Folz-Donahue, K., Hinze, Y., Mesaros, A., Hoey, D., Giavalisco, P., Dowell, R., Partridge, L., and Tessarz, P., “Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells”, Nature Aging,  1(9): p. 810-825 2021. https://doi.org/10.1038/s43587-021-00105-8

Schiffer, I., Gerisch, B., Kawamura, K., Laboy, R., Hewitt, J., Denzel, M.S., Mori, M.A., Vanapalli, S., Shen, Y., Symmons, O., and Antebi, A., “miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging”, eLife,  10: p. e66768 2021. https://doi.org/10.7554/eLife.66768

Sprenger, H.G., MacVicar, T., Bahat, A., Fiedler, K.U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N., Larsson, N.G., Nolte, H., Giavalisco, P., and Langer, T., “Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity”, Nat Metab,  3(5): p. 636-650 2021. https://doi.org/10.1038/s42255-021-00385-9

Tain, L.S., Sehlke, R., Meilenbrock, R.L., Leech, T., Paulitz, J., Chokkalingam, M., Nagaraj, N., Gronke, S., Frohlich, J., Atanassov, I., Mann, M., Beyer, A., and Partridge, L., “Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila”, Elife,  10 2021. https://doi.org/10.7554/eLife.67275

Talyan, S., Filipow, S., Ignarski, M., Smieszek, M., Chen, H., Kuhne, L., Butt, L., Gobel, H., Hoyer-Allo, K.J.R., Koehler, F.C., Altmuller, J., Brinkkotter, P., Schermer, B., Benzing, T., Kann, M., Muller, R.U., and Dieterich, C., “CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease”, Cells,  10(3): p. 692 2021. https://doi.org/10.3390/cells10030692


Balaji, V. and Hoppe, T., “Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly”, F1000Res,  9: p. F1000 Faculty Rev-88 2020. https://doi.org/10.12688/f1000research.21253.1

Bayer, E.A., Stecky, R.C., Neal, L., Katsamba, P.S., Ahlsen, G., Balaji, V., Hoppe, T., Shapiro, L., Oren-Suissa, M., and Hobert, O., “Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior”, Elife,  9: p. e59614 2020. https://doi.org/10.7554/eLife.59614

Bonfiglio, J.J., Leidecker, O., Dauben, H., Longarini, E.J., Colby, T., San Segundo-Acosta, P., Perez, K.A., and Matic, I., “An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation”, Cell,  183(4): p. 1086-1102 e23 2020. https://doi.org/10.1016/j.cell.2020.09.055

Bradshaw, W.J. and Valenzano, D.R., “Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes”, Proc Biol Sci,  287(1927): p. 20200489 2020. https://doi.org/10.1098/rspb.2020.0489

Fernandes, S.A.,C.F. Almeida, L.S. Souza, M. Lazar, P. Onofre-Oliveira, G.L. Yamamoto, L. Nogueira, L.Y. Tasaki, R.R. Cardoso, R.C.M. Pavanello, H.C.A. Silva, M.F.R. Ferrari, A. Bigot, V. Mouly, M. Vainzof, "Altered in vitro muscle differentiation in X-linked myopathy with excessive autophagy", Disease Models & Mechanisms, 13, dmm.041244, 2020. https://doi.org/10.1242/dmm.041244 

Gerisch, B., Tharyan, R.G., Mak, J., Denzel, S.I., Popkes-van Oepen, T., Henn, N., and Antebi, A., “HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence”, Dev Cell,  53(3): p. 316-329 e5 2020. https://doi.org/10.1016/j.devcel.2020.03.014

Hansen, J.N., Kaiser, F., Klausen, C., Stuven, B., Chong, R., Bonigk, W., Mick, D.U., Moglich, A., Jurisch-Yaksi, N., Schmidt, F.I., and Wachten, D., “Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium”, Elife,  9: p. e57907 2020. https://doi.org/10.7554/eLife.57907

Horn, M., Denzel, S.I., Srinivasan, B., Allmeroth, K., Schiffer, I., Karthikaisamy, V., Miethe, S., Breuer, P., Antebi, A., and Denzel, M.S., “Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response”, iScience,  23(3): p. 100887 2020. https://doi.org/10.1016/j.isci.2020.100887

Hos, N.J., Fischer, J., Hos, D., Hejazi, Z., Calabrese, C., Ganesan, R., Murthy, A.M.V., Rybniker, J., Kumar, S., Kronke, M., and Robinson, N., “TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection”, J Immunol,  205(9): p. 2456-2467 2020. https://doi.org/10.4049/jimmunol.2000048

Jais, A., Paeger, L., Sotelo-Hitschfeld, T., Bremser, S., Prinzensteiner, M., Klemm, P., Mykytiuk, V., Widdershooven, P.J.M., Vesting, A.J., Grzelka, K., Minere, M., Cremer, A.L., Xu, J., Korotkova, T., Lowell, B.B., Zeilhofer, H.U., Backes, H., Fenselau, H., Wunderlich, F.T., Kloppenburg, P., and Bruning, J.C., “PNOC(ARC) Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding”, Neuron,  106(6): p. 1009-1025 e10 2020. https://doi.org/10.1016/j.neuron.2020.03.022

Kim, C.S., D. Xiaolei, K. Allmeroth, M.S. Denzel, S. A. Eming, S. A. Wickström, "Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle", Cell Matabolism,2020 Sep 8,https://doi.org/10.1016/j.cmet.2020.08.011

Llamas, E., Alirzayeva, H., Loureiro, R., and Vilchez, D., “The intrinsic proteostasis network of stem cells”, Curr Opin Cell Biol,  67: p. 46-55 2020. https://doi.org/10.1016/j.ceb.2020.08.005

Mittenbuhler, M.J., Saedler, K., Nolte, H., Kern, L., Zhou, J., Qian, S.B., Meder, L., Ullrich, R.T., Bruning, J.C., and Wunderlich, F.T., “Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo”, Mol Metab,  42: p. 101085 2020. https://doi.org/10.1016/j.molmet.2020.101085

Meyer, D. H., B. Schumacher, "A transcriptome based aging clock near the theoretical limit of accuracy", bioRxiv, 31 May 2020, https://doi.org/10.1101/2020.05.29.123430

Motori, E., Atanassov, I., Kochan, S.M.V., Folz-Donahue, K., Sakthivelu, V., Giavalisco, P., Toni, N., Puyal, J., and Larsson, N.G., “Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction”, Sci Adv,  6(35): p. eaba8271 2020. https://doi.org/10.1126/sciadv.aba8271

Pradas-Juni, M., Hansmeier, N.R., Link, J.C., Schmidt, E., Larsen, B.D., Klemm, P., Meola, N., Topel, H., Loureiro, R., Dhaouadi, I., Kiefer, C.A., Schwarzer, R., Khani, S., Oliverio, M., Awazawa, M., Frommolt, P., Heeren, J., Scheja, L., Heine, M., Dieterich, C., Buning, H., Yang, L., Cao, H., Jesus, D.F., Kulkarni, R.N., Zevnik, B., Troder, S.E., Knippschild, U., Edwards, P.A., Lee, R.G., Yamamoto, M., Ulitsky, I., Fernandez-Rebollo, E., Vallim, T.Q.A., and Kornfeld, J.W., “A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism”, Nat Commun,  11(1): p. 644 2020. https://doi.org/10.1038/s41467-020-14323-y

Ruegenberg, S., Horn, M., Pichlo, C., Allmeroth, K., Baumann, U., and Denzel, M.S., “Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis”, Nat Commun,  11(1): p. 687 2020. https://doi.org/10.1038/s41467-020-14524-5

Stankovic, D., Claudius, A.K., Schertel, T., Bresser, T., and Uhlirova, M., “A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8”, Dis Model Mech,  13(6): p. dmm043174 2020. https://doi.org/10.1242/dmm.043174

Schiffer, I. B. Gerisch, K. Kawamura, R. Laboy, J. Hewitt, M. S. Denzel, M. A. Mori, S. Vanapalli, Y. Shen, O. Symmons, A. Antebi, "miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing" (preprint), doi: https://doi.org/10.1101/2021.01.21.427623

Szczepanowska, K., Senft, K., Heidler, J., Herholz, M., Kukat, A., Hohne, M.N., Hofsetz, E., Becker, C., Kaspar, S., Giese, H., Zwicker, K., Guerrero-Castillo, S., Baumann, L., Kauppila, J., Rumyantseva, A., Muller, S., Frese, C.K., Brandt, U., Riemer, J., Wittig, I., and Trifunovic, A., “A salvage pathway maintains highly functional respiratory complex I”, Nat Commun,  11(1): p. 1643 2020. https://doi.org/10.1038/s41467-020-15467-7

Tharyan, R.G., A. Annibal, I. Schiffer, R.Laboy, I. Atanassov, A.L. Weber, B. Gerisch, A. Antebi, "NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin", Nature Metabolism, 2(5): p. 387-396, 2020. https://doi.org/10.1038/s42255-020-0200-2

Thiruvalluvan, A., de Mattos, E.P., Brunsting, J.F., Bakels, R., Serlidaki, D., Barazzuol, L., Conforti, P., Fatima, A., Koyuncu, S., Cattaneo, E., Vilchez, D., Bergink, S., Boddeke, E., Copray, S., and Kampinga, H.H., “DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis”, Mol Cell, 78(2): p. 346-358 e9 2020. https://doi.org/10.1016/j.molcel.2020.02.022

Wang, S., Meyer, D.H., and Schumacher, B., “H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage”, Nat Struct Mol Biol,  27(12): p. 1165-1177 2020. https://doi.org/10.1038/s41594-020-00513-1



Aleman, F. D. D., D. R. Valenzano, "Microbiome evolution during host aging", 15(7), PLoS Pathog, 2019.

Busch, J.D., Cipullo, M., Atanassov, I., Bratic, A., Silva Ramos, E., Schondorf, T., Li, X., Pearce, S.F., Milenkovic, D., Rorbach, J., and Larsson, N.G., “MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition”, Cell Rep,  29(6): p. 1728-1738 e9 2019.

Chapard, C., R. Jones, T. van Oepen, J.C. Scheinost, K. Nasmyth, "Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex", Jul 25; 75(2): 224–237, Mol Cell, 2019.

Cui, R., Medeiros, T., Willemsen, D., Iasi, L.N.M., Collier, G.E., Graef, M., Reichard, M., and Valenzano, D.R., “Relaxed Selection Limits Lifespan by Increasing Mutation Load”, Cell,  178(2): p. 385-399 e20 2019.

da Silva, P. F. L., M. Ogrodnik, O. Kucheryavenko, et al., "The bystander effect contributes to the accumulation of senescent cells in vivo", 18, Aging Cell, 2019.

da Silva, P.F.L. and Schumacher, B., “DNA damage responses in ageing”, Open Biol,  9(11): p. 190168 2019.

Debès, C., A.C. Leote, A. Beyer, "Computational approaches for the systematic analysis of aging-associated molecular alterations", 27, pp.51-59, Drug Discovery Today: Disease Models, 2019.

Doll, M.A., Soltanmohammadi, N., and Schumacher, B., “ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans”, Genetics,  213(1): p. 173-194 2019.

Finger, F., Ottens, F., Springhorn, A., Drexel, T., Proksch, L., Metz, S., Cochella, L., and Hoppe, T., “Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling”, Nat Metab,  1(3): p. 350-359 2019.

Fischer, J., Gutierrez, S., Ganesan, R., Calabrese, C., Ranjan, R., Cildir, G., Hos, N.J., Rybniker, J., Wolke, M., Fries, J.W.U., Tergaonkar, V., Plum, G., Antebi, A., and Robinson, N., “Leptin signaling impairs macrophage defenses against Salmonella Typhimurium”, Proc Natl Acad Sci U S A,  116(33): p. 16551-16560 2019.

Hammerschmidt, P., Ostkotte, D., Nolte, H., Gerl, M.J., Jais, A., Brunner, H.L., Sprenger, H.G., Awazawa, M., Nicholls, H.T., Turpin-Nolan, S.M., Langer, T., Kruger, M., Brugger, B., and Bruning, J.C., “CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity”, Cell,  177(6): p. 1536-1552 e23 2019.

Hansmeier, N.R., Widdershooven, P.J.M., Khani, S., and Kornfeld, J.W., “Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology”, Noncoding RNA,  5(1): p. 12 2019.

Ivanova, S., M. Polajnar, A. J. Narbona-Perez, M. I. Hernandez-Alvarez, P. Frager, K. Slobodnyuk, N. Plana, A. R. Nebreda, M. Palacin, R. R. Gomis, C. Behrends, A. Zorzano, "Regulation of death receptor signaling by the autophagy protein", EMBO J, 2019.

Jachimowicz, R.D., Beleggia, F., Isensee, J., Velpula, B.B., Goergens, J., Bustos, M.A., Doll, M.A., Shenoy, A., Checa-Rodriguez, C., Wiederstein, J.L., Baranes-Bachar, K., Bartenhagen, C., Hertwig, F., Teper, N., Nishi, T., Schmitt, A., Distelmaier, F., Ludecke, H.J., Albrecht, B., Kruger, M., Schumacher, B., Geiger, T., Hoon, D.S.B., Huertas, P., Fischer, M., Hucho, T., Peifer, M., Ziv, Y., Reinhardt, H.C., Wieczorek, D., and Shiloh, Y., “UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors”, Cell,  176(3): p. 505-519 e22 2019.

Jiang, S., Koolmeister, C., Misic, J., Siira, S., Kuhl, I., Silva Ramos, E., Miranda, M., Jiang, M., Posse, V., Lytovchenko, O., Atanassov, I., Schober, F.A., Wibom, R., Hultenby, K., Milenkovic, D., Gustafsson, C.M., Filipovska, A., and Larsson, N.G., “TEFM regulates both transcription elongation and RNA processing in mitochondria”, EMBO Rep,  20(6): p. e48101 2019.

Klausen, C., Kaiser, F., Stuven, B., Hansen, J.N., and Wachten, D., “Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors”, Biochem Soc Trans,  47(6): p. 1733-1747 2019.

Lausch, M., M. Bartusel, R. Rehimi, H. Alirzayeva, A. Karaolidou, G. Crispatzu, P. Zentis, M. Nikolic, T. Bleckwehl, P. Kolovos, W. FJ van Ijcken, T. Šarić, K. Koehler, P. Frommolt, K. Lachlan, J. Baptista, A. Rada-Iglesias,  “Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs”. Cell Stem Cell. 2019 May 2; 24(5): 736-752.

Lee, H.J., Noormohammadi, A., Koyuncu, S., Calculli, G., Simic, M.S., Herholz, M., Trifunovic, A., and Vilchez, D., “Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans”, Nat Metab,  1(8): p. 790-810 2019.

MacVicar, T., Ohba, Y., Nolte, H., Mayer, F.C., Tatsuta, T., Sprenger, H.G., Lindner, B., Zhao, Y., Li, J., Bruns, C., Kruger, M., Habich, M., Riemer, J., Schwarzer, R., Pasparakis, M., Henschke, S., Bruning, J.C., Zamboni, N., and Langer, T., “Lipid signalling drives proteolytic rewiring of mitochondria by YME1L”, Nature,  575(7782): p. 361-365 2019.

Medeiros, T.C. and Graef, M., “Autophagy determines mtDNA copy number dynamics during starvation”, Autophagy,  15(1): p. 178-179 2019.

Morón-Oset, J., T. Supèr, J. Esser et al., "Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain". Acta neuropathol commun, 7, 209 (2019).

Ostermann, A.L., Wunderlich, C.M., Schneiders, L., Vogt, M.C., Woeste, M.A., Belgardt, B.F., Niessen, C.M., Martiny, B., Schauss, A.C., Frommolt, P., Nikolaev, A., Hovelmeyer, N., Sears, R.C., Koch, P.J., Gunzel, D., Bruning, J.C., and Wunderlich, F.T., “Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer”, Nat Metab,  1(3): p. 371-389 2019.

Ribeiro Jr. A.F., L.S. Souza, C.F. Almeida, R. Ishiba, S.A. Fernandes, D.A. Guerrieri, A.L.F. Santos, P.C.G Onofre-Oliveira, M. Vainzo, "Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies", Aug 14, 9:11842, Scientific Reports, 2019.

Saez, I., Gerbracht, J.V., Koyuncu, S., Lee, H.J., Horn, M., Kroef, V., Denzel, M.S., Dieterich, C., Gehring, N.H., and Vilchez, D., “The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells”, FEBS Lett,  594(1): p. 175-188 2019.

Silva Ramos, E., Motori, E., Bruser, C., Kuhl, I., Yeroslaviz, A., Ruzzenente, B., Kauppila, J.H.K., Busch, J.D., Hultenby, K., Habermann, B.H., Jakobs, S., Larsson, N.G., and Mourier, A., “Mitochondrial fusion is required for regulation of mitochondrial DNA replication”, PLoS Genet,  15(6): p. e1008085 2019.

Sprenger, H.G. and Langer, T., “The Good and the Bad of Mitochondrial Breakups”, Trends Cell Biol,  29(11): p. 888-900 2019.

Sprenger, H.G., Wani, G., Hesseling, A., Konig, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., and Langer, T., “Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy”, EMBO Mol Med,  11(1) 2019.


Bacman, S.R., Kauppila, J.H.K., Pereira, C.V., Nissanka, N., Miranda, M., Pinto, M., Williams, S.L., Larsson, N.G., Stewart, J.B., and Moraes, C.T., “MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation”, Nat Med,  24(11): p. 1696-1700 2018.

Balaji, V., W. Pokrzywa, and T. Hoppe, “Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis,” BioEssays, vol. 1700223, pp. 1–10, 2018.

Brandt, C., Nolte, H., Henschke, S., Engstrom Ruud, L., Awazawa, M., Morgan, D.A., Gabel, P., Sprenger, H.G., Hess, M.E., Gunther, S., Langer, T., Rahmouni, K., Fenselau, H., Kruger, M., and Bruning, J.C., “Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation”, Cell,  175(5): p. 1321-1335 e20 2018.

de Vrij, F. M., C. G. Bouwkamp, N. Gunhanlar, G. Shpak, B. Lendemeijer, M. Baghdadi, S. Gopalakrishna, M. Ghazvini, T. M. Li, M. Quadri, S. Olgiati, G. J. Breedveld, M. Coesmans, E. Mientjes, T. de Wit, F. W. Verheijen, H. B. Beverloo, D. Cohen, R. M. Kok, P. R. Bakker, A. Nijburg, A. T. Spijker, P. M. J. Haffmans, E. Hoencamp, V. Bergink, J. A. Vorstman, T. Wu, L. M. Olde Loohuis, N. Amin, C. D. Langen, A. Hofman, W. J. Hoogendijk, C. M. van Duijn, M. A. Ikram, M. W. Vernooij, H. Tiemeier, A. G. Uitterlinden, Y. Elgersma, B. Distel, J. Gribnau, T. White, V. Bonifati, and S. A. Kushner, “Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia,” Molecular Psychiatry, pp. 1–15, 2018.

Debès, C., Leote, A.C., and Beyer, A., “Computational approaches for the systematic analysis of aging-associated molecular alterations”, Drug Discovery Today: Disease Models,  27: p. 51-59 2018.

Gupta, R., Somyajit, K., Narita, T., Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, N., Nussenzweig, A., Lukas, J., and Choudhary, C., “DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity”, Cell,  173(4): p. 972-988 e23 2018.

Horn, M., Kroef, V., Allmeroth, K., Schuller, N., Miethe, S., Peifer, M., Penninger, J.M., Elling, U., and Denzel, M.S., “Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells”, Oncotarget,  9(11): p. 9838-9851 2018.

Kern, L., M. J. Mittenbühler, A. J. Vesting, A. L. Ostermann, C. M. Wunderlich, F. T. Wunderlich, “Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers”, Cancers, 2018.

Kremer, M., Kuhlmann, N., Lechner, M., Baldus, L., and Lammers, M., “Comment on 'YcgC represents a new protein deacetylase family in prokaryotes'”, Elife,  7: p. e37798 2018.

Koyuncu, S., Saez, I., Lee, H.J., Gutierrez-Garcia, R., Pokrzywa, W., Fatima, A., Hoppe, T., and Vilchez, D., “The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients”, Nat Commun,  9(1): p. 2886 2018.

Medeiros, T. C., R. L. Thomas, R. Ghillebert, and M. Graef, “Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation.,” J. Cell Biol., p. jcb.201801168, 2018.

Mittenbühler, M.J., H-G Sprenger, S. Gruber, C. M. Wunderlich, L. Kern, J. C. Brüning, F. T. Wunderlich, “Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma”, Mol. Met., 2018.

Noormohammadi, A., Calculli, G., Gutierrez-Garcia, R., Khodakarami, A., Koyuncu, S., and Vilchez, D., “Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells”, Cell Mol Life Sci,  75(2): p. 275-290 2018.

Ou, H.-L. and B. Schumacher, “DNA damage responses and p53 in the aging process,” Blood, vol. 131, no. 5, pp. 488–495, 2018.

Patron, M., H.-G. Sprenger, and T. Langer, “m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration,” Cell Res., vol. 28, no. 3, pp. 296–306, 2018.

Rieckher, M., Bujarrabal, A., Doll, M.A., Soltanmohammadi, N., and Schumacher, B., “A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes”, J Cell Physiol,  233(4): p. 2781-2790 2018.

Saez, I., S. Koyuncu, R. Gutierrez-Garcia, C. Dieterich, and D. Vilchez, “Insights into the ubiquitin-proteasome system of human embryonic stem cells,” Sci. Rep., vol. 8, no. 1, 2018.

Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N.R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P., Orom, U.A., Heeren, J., Bluher, M., Bilban, M., and Kornfeld, J.W., “LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat”, Nat Commun,  9(1): p. 3622 2018.

Welcker, D.*, M. Jain*, S. Khurshid*, M. Jokić, M. Höhne, A. Schmitt, P. Frommolt, C. M. Niessen, J. Spiro, T. Persigehl, M. Wittersheim, R. Büttner, M. Fanciulli, B. Schermer, H. C. Reinhardt, T. Benzing, and K. Höpker, “AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer,” Oncogene, vol. 37, no. 11, pp. 1503–1518, 2018.

Wunderlich, C.M., Ackermann, P.J., Ostermann, A.L., Adams-Quack, P., Vogt, M.C., Tran, M.L., Nikolajev, A., Waisman, A., Garbers, C., Theurich, S., Mauer, J., Hovelmeyer, N., and Wunderlich, F.T., “Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment”, Nat Commun,  9(1): p. 1646 2018.


Amin, N., F. De Vrij, M. Baghdadi, R. Brouwer, J. Van Rooij, O. Jovanova, A. Uitterlinden, A. Hofman, H. Janssen, S. D. Murad, R. Kraaij, J. Stedehouder, M. Van Den Hout, J. Kros, W. Van Ijcken, H. Tiemeier, S. Kushner, and C. Van Duijn, “A rare missense variant in RCL1 segregates with depression in extended families,” Molec. Psych., vol. 21, no. 10, pp. 1–7, 2017.

Artoni, F., Kreipke R.E., Palmeira, O., Dixon C., Goldberg, Z., Ruohola-Baker H. (2017). “Loss of foxo rescues stem cell aging in Drosophila germ line”. eLife, 2017.

Ganesan, R., N. J. Hos, S. Gutierrez, J. Fischer, N. Robinson, M. Stepek, E. Daglidu, and M. Kro, “Salmonella Typhimurium disrupts Sirt1 / AMPK checkpoint control of mTOR to impair autophagy,” PLOS Pathog., 13(2), pp. 1–22, 2017.

Ibn-Salem, J., S. Meiers, O. Eigenbrod, R. Sehlke, S. Talyan, K. Schwan, R. Otto, A. Pataskar, F. Metge, and P. Angerer, “Highlights of the 1st Student Symposium on Computational Genomics,” Genomics Comput. Biol., vol. 2, no. 1, p. e59, 2017.

Koyuncu, S., A. Fatima, R. Gutierrez-Garcia, and D. Vilchez, “Proteostasis of huntingtin in health and disease,” International Journal of Molecular Sciences, vol. 18, no. 7. 2017.

Kohli P, Höhne M, Jungst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B, The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep 18(9):1521-1535, 2017. doi: 10.15252/embr.201643846

Kühl, I.*, M. Miranda*, I. Atanassov, I. Kuznetsova, Y. Hinze, A. Mourier, A. Filipovska, and N. G. Larsson, “Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals,” Elife, vol. 6, 2017.

Liu, H.*, J. A. Dowdle*, S. Khurshid*, N. J. Sullivan, N. Bertos, K. Rambani, M. Mair, P. Daniel, E. Wheeler, X. Tang, K. Toth, M. Lause, M. E. Harrigan, K. Eiring, C. Sullivan, M. J. Sullivan, S. W. Chang, S. Srivastava, J. S. Conway, R. Kladney, J. McElroy, S. Bae, Y. Lu, A. Tofigh, S. M. I. Saleh, S. A. Fernandez, J. D. Parvin, V. Coppola, E. R. Macrae, S. Majumder, C. L. Shapiro, L. D. Yee, B. Ramaswamy, M. Hallett, M. C. Ostrowski, M. Park, H. M. Chamberlin, and G. Leone, “Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation,” Dev. Cell, vol. 41, no. 4, p. 392–407.e6, 2017.

López-Noriega, L., N. Cobo-Vuilleumier, Á. J. Narbona-Pérez, J. L. Araujo-Garrido, P. I. Lorenzo, J. M. Mellado-Gil, J. C. Moreno, B. R. Gauthier, A. Martín-Montalvo, "Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice", Br J Pharmacol, 2017.

Moosa, S., H. Böhrer-Rabel, J. Altmüller, F. Beleggia, P. Nürnberg, Y. Li, G. Yigit, and B. Wollnik, “Smith-Kingsmore syndrome: A third family with the MTOR mutation c.5395G>A p.(Glu1799Lys) and evidence for paternal gonadal mosaicism,” Am. J. Med. Genet. Part A, vol. 173, no. 1, pp. 264–267, 2017.

Rinschen, M. M., F. Grahammer, A. Hoppe, P. Kohli, H. Hagmann, O. Kretz, S. Bertsch, M. Höhne, H. Göbel, M. P. Bartram, R. K. Gandhirajan, M. Krüger, P. Brinkkoetter, T. B. Huber, M. Kann, and S. A. Wickström, “YAP-mediated mechanotransduction determines the podocyte ’ s response to damage,” Sci Signal., vol. 8165, no. April, pp. 1–16, 2017.

Tain, L. S.*, R. Sehlke*, C. Jain, M. Chokkalingam, N. Nagaraj, P. Essers, M. Rassner, S. Grönke, J. Froelich, C. Dieterich, M. Mann, N. Alic, A. Beyer, and L. Partridge, “A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance,” Mol. Syst. Biol., vol. 13, no. 9, p. 939, 2017.

Tawo, R., W. Pokrzywa, E. Kevei, M. E. Akyuz, V. Balaji, S. Adrian, J. Höhfeld, and T. Hoppe, “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover,” Cell, vol. 169, pp. 470–482, 2017.

Van, T.-M., A. Polykratis, B. K. Straub, V. Kondylis, N. Papadopoulou, and M. Pasparakis, “Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis,” J. Clin. Invest., vol. 127, no. 7, pp. 2662–2677, 2017.

Weir, H. J., P. Yao, F. K. Huynh, C. C. Escoubas, R. L. Goncalves, K. Burkewitz, R. Laboy, M. D. Hirschey, and W. B. Mair, “Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling,” Cell Metab., vol. 26, no. 6, p. 884–896.e5, 2017.


Aguilar-Lopez, J. L., R. Laboy, F. Jaimes-Miranda, E. Garay, A. DeLuna, and S. Funes, “Slm35 links mitochondrial stress response and longevity through TOR signaling pathway,” Aging (Albany. NY)., vol. 8, no. 12, pp. 3255–3271, 2016.

Burnouf, S., S. Grönke, H. Augustin, J. Dols, M. K. Gorsky, J. Werner, F. Kerr, N. Alic, P. Martinez, and L. Partridge, “Deletion of endogenous Tau proteins is not detrimental in Drosophila.,” Sci. Rep., vol. 6, no. February, p. 23102, 2016.

Bögershausen, N., U. Altunoglu, F. Beleggia, G. Yigit, H. Kayserili, P. Nürnberg, Y. Li, J. Altmüller, and B. Wollnik, “An unusual presentation of Kabuki syndrome with orbital cysts, microphthalmia, and cholestasis with bile duct paucity,” Am. J. Med. Genet. Part A, vol. 170, no. 12, pp. 3282–3288, 2016.

Cacciola, N. A., C. Calabrese, U. Malapelle, G. Pellino, A. De Stefano, R. Sepe, R. Sgariglia, C. Quintavalle, A. Federico, A. Bianco, A. Uchimura Bastos, M. Milone, C. Bellevicine, F. Milone, C. Carlomagno, F. Selvaggi, G. Troncone, A. Fusco, and P. Pallante, “UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients,” Mol. Carcinog., vol. 55, no. 5, pp. 793–807, 2016.

Cimen, I., B. Kocaturk, S. Koyuncu, O. Tufanl , U. I. Onat, A. D. Y ld r m, O. Apayd n,  eyma Demirsoy, Z. G. Aykut, U. T. Nguyen, S. M. Watkins, G. S. Hotam  l gil, and E. Erbay, “Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation,” Sci. Transl. Med., vol. 8, no. 358, p. 358ra126-358ra126, 2016. 

Glenewinkel, F., M. J. Cohen, C. R. King, S. Kaspar, S. Bamberg-Lemper, J. S. Mymryk, and W. Becker, “The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2,” Sci. Rep., vol. 6, no. 1, p. 28241, 2016. 

Gorsky, M. K., S. Burnouf, J. Dols, E. Mandelkow, and L. Partridge, “Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.,” Sci Rep, vol. 6, no. February, p. 22685, 2016.

Guelinckx, I., G. Tavoularis, J. König, C. Morin, H. Gharbi, and J. Gandy, “Contribution of water from food and fluids to total water intake: Analysis of a French and UK population surveys,” Nutrients, vol. 8, no. 10, 2016.

Hatzold, J., F. Beleggia, H. Herzig, J. Altmüller, P. Nürnberg, W. Bloch, B. Wollnik, and M. Hammerschmidt, “Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit,” Elife, vol. 5, no. MAY2016, 2016.

Kochan, D. Z. and O. Kovalchuk, “Circadian disruption-induced breast cancer - knowns and unknowns,” Cell Cycle, vol. 15, no. 5. pp. 613–614, 2016.

Kochan, D. Z., Y. Ilnytskyy, A. Golubov, S. H. Deibel, R. J. McDonald, and O. Kovalchuk, “Circadian-disruption-induced gene expression changes in rodent mammary tissues.,” Oncoscience, vol. 3, no. 2, pp. 58–70, 2016.

Koehler, S., S. Brähler, A. Kuczkowski, J. Binz, M. J. Hackl, H. Hagmann, M. Höhne, M. C. Vogt, C. M. Wunderlich, F. T. Wunderlich, F. Schweda, B. Schermer, T. Benzing, and P. T. Brinkkoetter, “Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.,” Sci. Rep., vol. 6, p. 35400, 2016.

Korwitz, A., C. Merkwirth, R. Richter-Dennerlein, S. E. Tröder, H. G. Sprenger, P. M. Quirós, C. López-Otín, E. I. Rugarli, and T. Langer, “Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria,” J. Cell Biol., vol. 212, no. 2, pp. 157–166, 2016.

König, T., S. E. Tröder, K. Bakka, A. Korwitz, R. Richter-Dennerlein, P. A. Lampe, M. Patron, M. Mühlmeister, S. Guerrero-Castillo, U. Brandt, T. Decker, I. Lauria, A. Paggio, R. Rizzuto, E. I. Rugarli, D. De Stefani, and T. Langer, “The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria,” Mol. Cell, vol. 64, no. 1, pp. 148–162, 2016.

Kühl, I., M. Miranda, V. Posse, D. Milenkovic, A. Mourier, S. J. Siira, N. A. Bonekamp, U. Neumann, A. Filipovska, P. L. Polosa, C. M. Gustafsson, and N.-G. Larsson, “POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.,” Sci. Adv., vol. 2, no. 8, p. e1600963, 2016.

Kühn, A. B., D. L. Feis, L. Schilbach, L. Kracht, M. E. Hess, J. Mauer, J. C. Brüning, and M. Tittgemeyer, “FTO gene variant modulates the neural correlates of visual food perception,” Neuroimage, vol. 128, pp. 21–31, 2016.

Lal, D., B. A. Neubauer, M. R. Toliat, J. Altmöller, H. Thiele, P. Nörnberg, C. Kamrath, A. Schänzer, T. Sander, A. Hahn, and M. Nothnagel, “Increased probability of co-occurrence of two rare diseases in consanguineous families and resolution of a complex phenotype by next generation sequencing,” PLoS One, vol. 11, no. 1, 2016.

Lal, D., E. M. Reinthaler, B. Dejanovic, P. May, H. Thiele, A. E. Lehesjoki, G. Schwarz, E. Riesch, M. A. Ikram, C. M. Van Duijn, A. G. Uitterlinden, A. Hofman, H. Steinböck, U. Gruber-Sedlmayr, B. Neophytou, F. Zara, A. Hahn, P. Gormley, F. Becker, Y. G. Weber, M. R. Cilio, W. S. Kunz, R. Krause, F. Zimprich, J. R. Lemke, P. Nürnberg, T. Sander, H. Lerche, et al., “Evaluation of presumably disease causing SCN1A variants in a cohort of common epilepsy syndromes,” PLoS One, vol. 11, no. 3, 2016.

Lemke, J. R., K. Geider, K. L. Helbig, H. O. Heyne, H. Schütz, J. Hentschel, C. Courage, C. Depienne, C. Nava, D. Heron, R. S. Møller, H. Hjalgrim, D. Lal, B. A. Neubauer, P. Nürnberg, H. Thiele, G. Kurlemann, G. L. Arnold, V. Bhambhani, D. Bartholdi, C. R. J. Pedurupillay, D. Misceo, E. Frengen, P. Strømme, D. J. Dlugos, E. S. Doherty, E. K. Bijlsma, et al., “Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy,” Neurology, vol. 86, no. 23, pp. 2171–2178, 2016.

Lin, J., S. Kumari, C. Kim, T. M. Van, L. Wachsmuth, A. Polykratis, and M. Pasparakis, “RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation,” Nature, pp. 1–16, 2016.

Lotan, Y., J. Antonelli, I. B. Jiménez, H. Gharbi, R. Herring, A. Beaver, A. Dennis, D. von Merveldt, S. Carter, A. Cohen, J. Poindexter, O. W. Moe, and M. S. Pearle, “The kidney stone and increased water intake trial in steel workers: results from a pilot study,” Urolithiasis, pp. 1–7, 2016.

Manjunath, G. P., N. Soni, P. L. Vaddavalli, D. J. Shewale, M. S. Madhusudhan, and K. Muniyappa, “Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA,” Biochemistry, vol. 55, no. 12, pp. 1850–1862, 2016.

Naranjo, J. R., H. Zhang, D. Villar, P. González, X. M. Dopazo, J. Morón-Oset, E. Higueras, J. C. Oliveros, M. D. Arrabal, A. Prieto, P. Cercós, T. González, A. De La Cruz, J. Casado-Vela, A. Rábano, C. Valenzuela, M. Gutierrez-Rodriguez, J. Y. Li, and B. Mellström, “Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease,” J. Clin. Invest., vol. 126, no. 2, pp. 627–638, 2016.

Naser, R., R. Vandenbosch, S. Omais, D. Hayek, C. Jaafar, S. Al Lafi, A. Saliba, M. Baghdadi, L. Skaf, and N. Ghanem, “Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb,” Sci. Rep., vol. 6, no. 1, p. 20230, 2016.

Pal, D. K., C. Ferrie, L. Addis, T. Akiyama, G. Capovilla, R. Caraballo, A. De Saint-Martin, N. Fejerman, R. Guerrini, K. Hamandi, I. Helbig, A. A. Ioannides, K. Kobayashi, D. Lal, G. Lesca, H. Muhle, B. A. Neubauer, T. Pisano, G. Rudolf, C. Seegmuller, T. Shibata, A. Smith, P. Striano, L. J. Strug, P. Szepetowski, T. Valeta, H. Yoshinaga, and M. Koutroumanidis, “Idiopathic focal epilepsies: The lost tribe,” Epileptic Disorders, vol. 18, no. 3. pp. 252–288, 2016.

Noormohammadi, A., A. Khodakarami, R. Gutierrez-Garcia, H. J. Lee, S. Koyuncu, T. König, C. Schindler, I. Saez, A. Fatima, C. Dieterich, and D. Vilchez, “Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan,” Nat. Commun., vol. 7, p. 13649, 2016.

Oliverio, M., E. Schmidt, J. Mauer, C. Baitzel, N. Hansmeier, S. Khani, S. Konieczka, M. Pradas-Juni, S. Brodesser, T. M. Van, D. Bartsch, H. S. Brönneke, M. Heine, H. Hilpert, E. Tarcitano, G. A. Garinis, P. Frommolt, J. Heeren, M. A. Mori, J. C. Brüning, and J.-W. Kornfeld, “Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.,” Nat. Cell Biol., vol. 18, no. 3, pp. 328–36, 2016.

Ou, H.-L., D. Sun, Y.-C. Peng, and Y.-L. Wu, “Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1 -induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells,” Innate Immun., vol. 22, no. 6, pp. 452–465, 2016.

Silva Ramos, E., N. G. Larsson, and A. Mourier, “Bioenergetic roles of mitochondrial fusion,” Biochim. Biophys. Acta - Bioenerg., vol. 1857, no. 8, pp. 1277–1283, 2016.

Steculorum, S. M., J. Ruud, I. Karakasilioti, H. Backes, L. Engström Ruud, K. Timper, M. E. Hess, E. Tsaousidou, J. Mauer, M. C. Vogt, L. Paeger, S. Bremser, A. C. Klein, D. A. Morgan, P. Frommolt, P. T. Brinkkötter, P. Hammerschmidt, T. Benzing, K. Rahmouni, F. T. Wunderlich, P. Kloppenburg, and J. C. Brüning, “AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue,” Cell, vol. 165, no. 1, pp. 125–138, 2016.

Teixeira, V., T. C. Medeiros, R. Vilaça, J. Ferreira, P. Moradas-Ferreira, and V. Costa, “Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells,” Biochim. Biophys. Acta - Mol. Cell Biol. Lipids, vol. 1861, no. 1, pp. 21–33, 2016.

Rinschen, M. M., P. Bharill, X. Wu, P. Kohli, M. J. Reinert, O. Kretz, I. Saez, B. Schermer, M. Höhne, M. P. Bartram, S. Aravamudhan, B. R. Brooks, D. Vilchez, T. B. Huber, R. U. Müller, M. Krüger, and T. Benzing, “The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes,” Hum. Mol. Genet., vol. 25, no. 7, pp. 1328–1344, 2016.

Seiferling, D., K. Szczepanowska, C. Becker, K. Senft, S. Hermans, P. Maiti, T. König, A. Kukat, and A. Trifunovic, “Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt,” EMBO Rep., vol. 17, no. 7, pp. 1–12, 2016.

Sukumaran, S. K., M. Stumpf, S. Salamon, I. Ahmad, K. Bhattacharya, S. Fischer, R. Müller, J. Altmüller, B. Budde, H. Thiele, M. Tariq, N. A. Malik, P. Nürnberg, S. M. Baig, M. S. Hussain, and A. A. Noegel, “CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly,” Mol. Genet. Genomics, vol. 292, no. 2, pp. 365–383, 2016.

Szczepanowska, K., P. Maiti, A. Kukat, E. Hofsetz, H. Nolte, K. Senft, C. Becker, B. Ruzzenente, H. Hornig‐Do, R. Wibom, R. J. Wiesner, M. Krüger, and A. Trifunovic, “CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels,” EMBO J., p. e201694253, 2016.

Tekin, B., D. Yucelten, F. Beleggia, O. Sarig, and E. Sprecher, “Papillon-Lefèvre syndrome: report of six patients and identification of a novel mutation,” Int. J. Dermatol., vol. 55, no. 8, pp. 898–902, 2016.

Trikha, P., N. Sharma, C. Pena, A. Reyes, T. Pécot, S. Khurshid, M. Rawahneh, J. Moffitt, J. A. Stephens, S. A. Fernandez, M. C. Ostrowski, and G. Leone, “E2f3 in tumor macrophages promotes lung metastasis,” Oncogene, vol. 35, no. 28, pp. 3636–3646, 2016.

Wai, T., S. Saita, H. Nolte, S. Müller, T. König, R. Richter-dennerlein, H. G. Sprenger, J. Madrenas, M. Mühlmeister, U. Brandt, M. Krüger, and T. Langer, “The membrane scaffold SLP 2 anchors a proteolytic hub in mitochondria containing PARL and the i -AAA protease YME 1 L,” EMBO Rep., vol. 17, no. 12, pp. 1844–1856, 2016.

Yigit, G., D. Wieczorek, N. Bögershausen, F. Beleggia, C. Möller-Hartmann, J. Altmüller, H. Thiele, P. Nürnberg, and B. Wollnik, “A syndrome of microcephaly, short stature, polysyndactyly, and dental anomalies caused by a homozygous KATNB1 mutation,” Am. J. Med. Genet. Part A, vol. 170, no. 3, pp. 728–733, 2016.


Beleggia, F., Y. Li, J. Fan, N. H. Elcioglu, E. Toker, T. Wieland, I. H. Maumenee, N. A. Akarsu, T. Meitinger, T. M. Strom, R. Lang, and B. Wollnik, “CRIM1 haploinsufficiency causes defects in eye development in human and mouse,” Hum. Mol. Genet., vol. 24, no. 8, pp. 2267–2273, 2015.

Boyadjiev, B. Wollnik, O. Semler, S. K. Bohlander, J. Kim, and C. Netzer, “Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta,” Am. J. Hum. Genet., vol. 96, no. 3, pp. 432–439, 2015.

Burnouf, S., M. K. Gorsky, J. Dols, S. Grönke, and L. Partridge, “Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo.,” Acta Neuropathol., vol. 130, no. 1, pp. 35–47, 2015.

Bögershausen, N., I. C. Tsai, E. Pohl, P. O. S. Kiper, F. Beleggia, E. Ferda Percin, K. Keupp, A. Matchan, E. Milz, Y. Alanay, H. Kayserili, Y. Liu, S. Banka, A. Kranz, M. Zenker, D. Wieczorek, N. Elcioglu, P. Prontera, S. Lyonnet, T. Meitinger, A. Francis Stewart, D. Donnai, T. M. Strom, K. Boduroglu, G. Yigit, Y. Li, N. Katsanis, and B. Wollnik, “RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome,” J. Clin. Invest., vol. 125, no. 9, pp. 3585–3599, 2015.

Chong, A. C. N., M. C. Vogt, A. S. Hill, J. C. Brüning, and L. M. Zeltser, “Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness,” Mol. Metab., vol. 4, no. 2, pp. 83–92, 2015.

Deckstein, J., J. van Appeldorn, M. Tsangarides, K. Yiannakou, R. Müller, M. Stumpf, S. K. Sukumaran, L. Eichinger, A. A. Noegel, and T. Y. Riyahi, “The Dictyostelium discoideum GPHR ortholog is an endoplasmic reticulum and golgi protein with roles during development,” Eukaryot. Cell, vol. 14, no. 1, pp. 41–54, 2015.

Dejanovic, B., T. Djemie, N. Gru newald, A. Suls, V. Kress, F. Hetsch, D. Craiu, M. Zemel, P. Gormley, D. Lal, C. T. Myers, H. C. Mefford, A. Palotie, I. Helbig, J. C. Meier, P. De Jonghe, S. Weckhuysen, and G. Schwarz, “Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy,” EMBO Mol. Med., vol. 7, no. 12, pp. 1580–1594, 2015.

Fei, F., E. J. Joo, S. S. Tarighat, I. Schiffer, H. Paz, M. Fabbri, H. Abdel-Azim, J. Groffen, and N. Heisterkamp, “B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3,” Oncotarget, vol. 6, no. 13, pp. 11378–11394, 2015.

Galizia, E. C., C. T. Myers, C. Leu, C. G. F. de Kovel, T. Afrikanova, M. L. Cordero-Maldonado, T. G. Martins, M. Jacmin, S. Drury, V. Krishna Chinthapalli, H. Muhle, M. Pendziwiat, T. Sander, A.-K. Ruppert, R. S. Møller, H. Thiele, R. Krause, J. Schubert, A.-E. Lehesjoki, P. Nürnberg, H. Lerche, A. Palotie, A. Coppola, S. Striano, L. Del Gaudio, C. Boustred, A. L. Schneider, N. Lench, B. Jocic-Jakubi, A. Covanis, G. Capovilla, P. Veggiotti, M. Piccioli, P. Parisi, L. Cantonetti, L. G. Sadleir, S. A. Mullen, S. F. Berkovic, U. Stephani, I. Helbig, A. D. Crawford, C. V. Esguerra, D. G. A. Kasteleijn-Nolst Trenité, B. P. C. Koeleman, H. C. Mefford, I. E. Scheffer, S. M. Sisodiya, Collaborators:, A. E. Folkhälsan, A. K. Ruppert, B. Koeleman, D. Lal, et al., “CHD2 variants are a risk factor for photosensitivity in epilepsy,” Brain, vol. 138, no. 5, pp. 1198–1208, 2015.

Garbes, L., K. Kim, A. Rieß, H. Hoyer-Kuhn, F. Beleggia, A. Bevot, M. J. Kim, Y. H. Huh, H. S. Kweon, R. Savarirayan, D. Amor, P. M. Kakadia, T. Lindig, K. O. Kagan, J. Becker, S. A. Boyadjiev, B. Wollnik, O. Semler, S. K. Bohlander, J. Kim, and C. Netzer, “Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta,” Am. J. Hum. Genet., vol. 96, no. 3, pp. 432–439, 2015.

Gray, M. J., P. Kannu, S. Sharma, C. Neyt, D. Zhang, N. Paria, P. B. Daniel, H. Whetstone, H. G. Sprenger, P. Hammerschmidt, A. Weng, L. Dupuis, R. Jobling, R. Mendoza-Londono, M. Dray, P. Su, M. J. Wilson, R. P. Kapur, E. F. McCarthy, B. A. Alman, A. Howard, G. R. Somers, C. R. Marshall, S. Manners, A. M. Flanagan, K. E. Rathjen, L. A. Karol, H. Crawford, D. M. Markie, J. J. Rios, C. A. Wise, and S. P. Robertson, “Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia,” Am. J. Hum. Genet., vol. 97, no. 6, pp. 837–847, 2015.

Hardies, K., C. G. F. De Kovel, S. Weckhuysen, B. Asselbergh, T. Geuens, T. Deconinck, A. Azmi, P. May, E. Brilstra, F. Becker, N. Barisic, D. Craiu, K. P. J. Braun, D. Lal, H. Thiele, J. Schubert, Y. Weber, R. Van ’T Slot, P. Nürnberg, R. Balling, V. Timmerman, H. Lerche, S. Maudsley, I. Helbig, A. Suls, B. P. C. Koeleman, P. De Jonghe, et al., “Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia,” Brain, vol. 138, no. 11, pp. 3238–3250, 2015.

Kelkar, P., A. Walter, S. Papadopoulos, C. Mross, M. Munck, V. S. Peche, and A. Noegel, “Nesprin-2 mediated nuclear trafficking and its clinical implications.,” Nucleus, vol. 1034, no. April, p. 0, 2015.

Khodakarami, A., I. Saez, J. Mels, and D. Vilchez, “Mediation of organismal aging and somatic proteostasis by the germline.,” Front. Mol. Biosci., vol. 2, p. 3, 2015.

Kondylis, V., A. Polykratis, H. Ehlken, L. Ochoa-Callejero, B. K. Straub, S. Krishna-Subramanian, T. M. Van, H. M. Curth, N. Heise, F. Weih, U. Klein, P. Schirmacher, M. Kelliher, and M. Pasparakis, “NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis,” Cancer Cell, vol. 28, no. 5, pp. 582–598, 2015.

Kochan, D. Z., Y. Ilnytskyy, A. Golubov, S. H. Deibel, R. J. McDonald, and O. Kovalchuk, “Circadian disruption-induced microRNAome deregulation in rat mammary gland tissues.,” Oncoscience, vol. 2, no. 4, pp. 428–442, 2015.

Kochan, D. Z. and O. Kovalchuk, “Circadian Disruption and Breast Cance: An epigenetic link?,” Oncotarget, vol. 6, no. 19, pp. 16866–16882, 2015.

Koyuncu, S., D. Irmak, I. Saez, and D. Vilchez, “Defining the General Principles of Stem Cell Aging : Lessons from Organismal Models,” Curr Stem Cell Rep, pp. 162–169, 2015.

Külshammer, E., J. Mundorf, M. Kilinc, P. Frommolt, P. Wagle, and M. Uhlirova, “Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.,” Dis. Model. Mech., vol. 8, no. 10, pp. 1279–93, 2015.

Lagouge, M., A. Mourier, H. J. Lee, H. Spahr, T. Wai, C. Kukat, E. Silva Ramos, E. Motori, J. D. Busch, S. Siira, E. Kremmer, A. Filipovska, and N. G. Larsson, “SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation,” PLoS Genet., vol. 11, no. 8, 2015.

Lal, D., K. Pernhorst, K. M. Klein, P. Reif, R. Tozzi, M. R. Toliat, G. Winterer, B. Neubauer, P. Nürnberg, F. Rosenow, F. Becker, H. Lerche, W. S. Kunz, M. I. Kurki, P. Hoffmann, A. J. Becker, E. Perucca, F. Zara, T. Sander, and Y. G. Weber, “Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy,” Epilepsia, vol. 56, no. 9, pp. e129–e133, 2015.

Lal, D., S. Steinbrücker, J. Schubert, T. Sander, F. Becker, Y. Weber, H. Lerche, H. Thiele, R. Krause, A. E. Lehesjoki, P. Nürnberg, A. Palotie, B. A. Neubauer, H. Muhle, U. Stephani, I. Helbig, A. J. Becker, S. Schoch, J. Hansen, T. Dorn, C. Hohl, N. Lüscher, S. von Spiczak, J. R. Lemke, et al., “Investigation of GRIN2A in common epilepsy phenotypes,” Epilepsy Res., vol. 115, pp. 95–99, 2015.

Lal, D., A. K. Ruppert, H. Trucks, H. Schulz, C. de Kovel, D. Kasteleijn-Nolst Trenité, A. C. M. Sonsma, B. P. Koeleman, D. Lindhout, Y. G. Weber, H. Lerche, C. Kapser, C. J. Schankin, W. S. Kunz, R. Surges, C. E. Elger, V. Gaus, B. Schmitz, I. Helbig, H. Muhle, U. Stephani, K. M. Klein, F. Rosenow, B. A. Neubauer, E. M. Reinthaler, F. Zimprich, M. Feucht, R. S. Møller, H. Hjalgrim, P. De Jonghe, A. Suls, W. Lieb, A. Franke, K. Strauch, C. Gieger, C. Schurmann, U. Schminke, P. Nürnberg, et al., “Burden Analysis of Rare Microdeletions Suggests a Strong Impact of Neurodevelopmental Genes in Genetic Generalised Epilepsies,” PLoS Genet., vol. 11, no. 5, 2015.

Mitsopoulos, P., Y.-H. Chang, T. Wai, T. König, S. D. Dunn, T. Langer, and J. Madrenas, “Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.,” Mol. Cell. Biol., vol. 35, no. 10, pp. 1838–47, 2015.

Peters, F., S. Vorhagen, S. Brodesser, K. Jakobshagen, J. C. Brüning, C. M. Niessen, and M. Krönke, “Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.,” J. Invest. Dermatol., vol. 135, no. 6, pp. 1501–9, 2015.

Reinthaler, E. M., B. Dejanovic, D. Lal, M. Semtner, Y. Merkler, A. Reinhold, D. A. Pittrich, C. Hotzy, M. Feucht, H. Steinböck, U. Gruber-Sedlmayr, G. M. Ronen, B. Neophytou, J. Geldner, E. Haberlandt, H. Muhle, M. A. Ikram, C. M. Van Duijn, A. G. Uitterlinden, A. Hofman, J. Altmüller, A. Kawalia, M. R. Toliat, P. Nürnberg, H. Lerche, M. Nothnagel, H. Thiele, T. Sander, J. C. Meier, G. Schwarz, B. A. Neubauer, and F. Zimprich, “Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes,” Ann. Neurol., vol. 77, no. 6, pp. 972–986, 2015.

Rosin, N., N. H. Elcioglu, F. Beleggia, P. Isgüven, J. Altmüller, H. Thiele, K. Steindl, P. Joset, A. Rauch, P. Nürnberg, B. Wollnik, and G. Yigit, “Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability,” Hum. Mol. Genet., vol. 24, no. 13, pp. 3708–3717, 2015.

Sevgi, M., L. Rigoux, A. B. Kühn, J. Mauer, L. Schilbach, M. E. Hess, T. O. J. Gruendler, M. Ullsperger, K. E. Stephan, J. C. Brüning, and M. Tittgemeyer, “An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning,” J. Neurosci., vol. 35, no. 36, pp. 12584–12592, 2015.

Singh, M., Z. Dai, H. Khong, C. Vianden, M. Cantwell, and W. Overwijk, “Induction of potent systemic anti-melanoma immunity through intratumoral CD40 activation and checkpoint blockade,” J. Immunother. Cancer, vol. 3, no. Suppl 2, p. P313, 2015.

Sukumaran, S. K., R. Blau-Wasser, M. Rohlfs, C. Gallinger, M. Schleicher, and A. A. Noegel, “The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway,” Cell Cycle, vol. 14, no. May, pp. 37–41, 2015.

Teixeira, V., T. C. Medeiros, R. Vilaça, A. T. Pereira, S. R. Chaves, M. Côrte-Real, P. Moradas-Ferreira, and V. Costa, “Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells,” Cell. Signal., vol. 27, no. 9, pp. 1840–1849, 2015.

Tennstaedt, A., M. Aswendt, J. Adamczak, U. Collienne, M. Selt, G. Schneider, N. Henn, C. Schaefer, M. Lagouge, D. Wiedermann, P. Kloppenburg, and M. Hoehn, “Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks,” Biomaterials, vol. 44, pp. 143–154, 2015.

Tischner, C., A. Hofer, V. Wulff, J. Stepek, I. Dumitru, L. Becker, T. Haack, L. Kremer, A. N. Datta, W. Sperl, T. Floss, W. W. Wurst, Z. Chrzanowska-Lightowlers, M. H. De Angelis, T. Klopstock, H. Prokisch, and T. Wenz, “MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention,” Hum. Mol. Genet., vol. 24, no. 8, pp. 2247–2266, 2015.

Vorhagen, S., J. Jackow, S. G. Mohor, G. Tanghe, L. Tanrikulu, C. Skazik-Vogt, and F. Tellkamp, “Lineage tracing mediated by cre-recombinase activity.,” J. Invest. Dermatol., vol. 135, no. 1, p. e28, 2015.


Dejanovic, B., D. Lal, C. B. Catarino, S. Arjune, A. A. Belaidi, H. Trucks, C. Vollmar, R. Surges, W. S. Kunz, S. Motameny, J. Altmüller, A. Köhler, B. A. Neubauer, EPICURE Consortium, P. Nürnberg, S. Noachtar, G. Schwarz, and T. Sander, “Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy,” Neurobiol. Dis., vol. 67, pp. 88–96, 2014.

Dogan, S. A., C. Pujol, P. Maiti, A. Kukat, S. Wang, S. Hermans, K. Senft, R. Wibom, E. I. Rugarli, and A. Trifunovic, “Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart,” Cell Metab., vol. 19, no. 3, pp. 458–469, 2014.

Hess, M. E. and J. C. Brüning, “The fat mass and obesity-associated (FTO) gene: Obesity and beyond?,” Biochim. Biophys. Acta - Mol. Basis Dis., vol. 1842, no. 10, pp. 2039–2047, 2014.

Horn, M., C. Geisen, L. Cermak, B. Becker, S. Nakamura, C. Klein, M. Pagano, and A. Antebi, “DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation,” Dev. Cell, vol. 28, no. 6, pp. 697–710, 2014.

Hussain, M. S., A. Battaglia, S. Szczepanski, E. Kaygusuz, M. R. Toliat, S. I. Sakakibara, J. Altmüller, H. Thiele, G. Nürnberg, S. Moosa, G. Yigit, F. Beleggia, S. Tinschert, J. Clayton-Smith, P. Vasudevan, J. E. Urquhart, D. Donnai, A. Fryer, F. Percin, F. Brancati, A. Dobbie, R. ͆migiel, G. Gillessen-Kaesbach, B. Wollnik, A. Anna Noegel, W. G. Newman, and P. Nürnberg, “Mutations in CKAP2L, the human homolog of the mouse radmis gene, cause filippi syndrome,” Am. J. Hum. Genet., vol. 95, no. 5, pp. 622–632, 2014.

Kloten, V., M. Rose, S. Kaspar, S. von Stillfried, R. Knüchel, and E. Dahl, “Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype,” Epigenetics, vol. 9, no. 9, pp. 1290–1301, 2014.

Kohli, P., M. P. Bartram, S. Habbig, C. Pahmeyer, T. Lamkemeyer, T. Benzing, B. Schermer, and M. M. Rinschen, “Label-free quantitative proteomic analysis of the YAP and TAZ interactome.,” Am. J. Physiol. Cell Physiol., 2014.

Kukat, A., S. A. Dogan, D. Edgar, A. Mourier, C. Jacoby, P. Maiti, J. Mauer, C. Becker, K. Senft, R. Wibom, A. P. Kudin, K. Hultenby, U. Flögel, S. Rosenkranz, D. Ricquier, W. S. Kunz, and A. Trifunovic, “Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity,” PLoS Genet., vol. 10, no. 6, 2014.

Kühl, I., C. Kukat, B. Ruzzenente, D. Milenkovic, A. Mourier, M. Miranda, C. Koolmeister, M. Falkenberg, and N.-G. Larsson, “POLRMT does not transcribe nuclear genes.,” Nature, vol. 514, no. 7521, pp. E7-11, 2014. 

Lal, D., E. M. Reinthaler, J. Schubert, H. Muhle, E. Riesch, G. Kluger, K. Jabbari, A. Kawalia, C. Bäumel, H. Holthausen, A. Hahn, M. Feucht, B. Neophytou, E. Haberlandt, F. Becker, J. Altmüller, H. Thiele, J. R. Lemke, H. Lerche, P. Nürnberg, T. Sander, Y. Weber, F. Zimprich, and B. A. Neubauer, “DEPDC5 mutations in genetic focal epilepsies of childhood,” Ann. Neurol., vol. 75, no. 5, pp. 788–792, 2014.

Mauer, J., B. Chaurasia, J. Goldau, M. C. Vogt, J. Ruud, K. Nguyen, S. Theurich, A. C. Hausen, J. Schmitz, H. S. Brönneke, E. Estevez, T. L. Allen, A. Mesaros, L. Partridge, M. A. Febbraio, A. Chawla, F. T. Wunderlich, and J. C. Brüning, “Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.,” Nat Immunol., vol. 15(5), pp. 423–430, 2014.

Parameswaran, R., M. Lim, F. Fei, H. Abdel-Azim, A. Arutyunyan, I. Schiffer, M. E. McLaughlin, H. Gram, H. Huet, J. Groffen, and N. Heisterkamp, “Effector-Mediated Eradication of Precursor B Acute Lymphoblastic Leukemia with a Novel Fc-Engineered Monoclonal Antibody Targeting the BAFF-R,” Mol. Cancer Ther., vol. 13, no. 6, pp. 1567–1577, 2014.

Pérez-Rodríguez, R., A. M. Oliván, C. Roncero, J. Morón-Oset, M. P. González, and M. J. Oset-Gasque, “Glutamate triggers neurosecretion and apoptosis in bovine chromaffin cells through a mechanism involving NO production by neuronal NO synthase activation,” Free Radic. Biol. Med., vol. 69, pp. 390–402, 2014.

Pichlo, M., S. Bungert-Plümke, I. Weyand, R. Seifert, W. Bönigk, T. Strünker, N. D. Kashikar, N. Goodwin, A. Müller, P. Pelzer, Q. Van, J. Enderlein, C. Klemm, E. Krause, C. Trötschel, A. Poetsch, E. Kremmer, U. B. Kaupp, H. G. Körschen, and U. Collienne, “High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor,” J. Cell Biol., vol. 206, no. 4, pp. 541–557, 2014.

Polykratis, A., N. Hermance, M. Zelic, J. Roderick, C. Kim, T. M. Van, T. H. Lee, F. K. Chan, M. Pasparakis, and M. A. Kelliher, “RIPK1 kinase inactive mice are viable and protected from TNF- induced necroptosis in vivo,” J Immunol., vol. 193(4), pp. 1539–1543, 2014.

Reinthaler, E. M., D. Lal, W. Jurkowski, M. Feucht, H. Steinböck, U. Gruber-Sedlmayr, G. M. Ronen, J. Geldner, E. Haberlandt, B. Neophytou, A. Hahn, J. Altmüller, H. Thiele, M. R. Toliat, H. Lerche, P. Nürnberg, T. Sander, B. A. Neubauer, and F. Zimprich, “Analysis of ELP4, SRPX2, and interacting genes in typical and atypical rolandic epilepsy,” Epilepsia, vol. 55, no. 8, 2014.

Reinthaler, E. M., D. Lal, S. Lebon, M. S. Hildebrand, H. H. M. Dahl, B. M. Regan, M. Feucht, H. Steinböck, B. Neophytou, G. M. Ronen, L. Roche, U. Gruber-Sedlmayr, J. Geldner, E. Haberlandt, P. Hoffmann, S. Herms, C. Gieger, M. Waldenberger, A. Franke, M. Wittig, S. Schoch, A. J. Becker, A. Hahn, K. Männik, M. R. Toliat, G. Winterer, H. Lerche, P. Nürnberg, H. Mefford, I. E. Scheffer, S. F. Berkovic, J. S. Beckmann, T. Sander, S. Jacquemont, A. Reymond, F. Zimprich, and B. A. Neubauer, “16p11.2 600 kb duplications confer risk for typical and atypical rolandic epilepsy,” Hum. Mol. Genet., vol. 23, no. 22, pp. 6069–6080, 2014.

Rinschen, M. M., X. Wu, T. König, T. Pisitkun, H. Hagmann, C. Pahmeyer, T. Lamkemeyer, P. Kohli, N. Schnell, B. Schermer, S. Dryer, B. R. Brooks, P. Beltrao, M. Krueger, P. T. Brinkkoetter, and T. Benzing, “Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration Barrier.,” J. Am. Soc. Nephrol., vol. 25, no. 7, pp. 1509–1522, 2014.

Schreml, J., B. Durmaz, O. Cogulu, K. Keupp, F. Beleggia, E. Pohl, E. Milz, M. Coker, S. K. Ucar, G. Nürnberg, P. Nürnberg, J. Kuhn, and F. Ozkinay, “The missing ‘link’: An autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation,” Hum. Genet., vol. 133, no. 1, pp. 29–39, 2014

Teixeira, V., T. C. Medeiros, R. Vilaça, P. Moradas-ferreira, and V. Costa, “Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells,” Microb. Cell, vol. 1, no. 1, pp. 21–36, 2014.

Tellkamp, F., S. Vorhagen, and C. M. Niessen, “Epidermal polarity genes in health and disease,” Cold Spring Harb. Perspect. Med., vol. 4, no. 12, 2014.

Tellkamp, F., F. Benhadou, J. Bremer, M. Gnarra, J. Knüver, S. Schaffenrath, and S. Vorhagen, “Transgenic Mouse Technology in Skin Biology: Generation of Knockin Mice,” J. Invest. Dermatol., vol. 134, no. 12, p. e27, 2014.

Tsaousidou, E., L. Paeger, B. F. Belgardt, M. Pal, C. M. Wunderlich, H. Brönneke, U. Collienne, B. Hampel, F. T. Wunderlich, M. Schmidt-Supprian, P. Kloppenburg, and J. C. Brüning, “Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance,” Cell Rep., vol. 9, no. 4, pp. 1495–1506, 2014.

Vogt, M. C., L. Paeger, S. Hess, S. M. Steculorum, M. Awazawa, B. Hampel, S. Neupert, H. T. Nicholls, J. Mauer, A. C. Hausen, R. Predel, P. Kloppenburg, T. L. Horvath, and J. C. Brüning, “Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding,” Cell, vol. 156, no. 3, pp. 495–509, 2014.



Demirci, S., E. Koban Baştanlar, N. D. Dağtaş, E. Pişkin, A. Engin, F. Ozer, E. Yüncü, S. A. Doğan, and I. Togan, “Mitochondrial DNA diversity of modern, ancient and wild sheep(Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep.,” PLoS One, vol. 8, no. 12, p. e81952, 2013.

Ermolaeva, M. A., A. Segref, A. Dakhovnik, H.-L. Ou, J. I. Schneider, O. Utermöhlen, T. Hoppe, and B. Schumacher, “DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.,” Nature, vol. 501, no. 7467, pp. 416–420, 2013.

Frank, V., S. Habbig, M. P. Bartram, T. Eisenberger, H. E. Veenstra-Knol, C. Decker, R. A. C. Boorsma, H. Göbel, G. Nürnberg, A. Griessmann, M. Franke, L. Borgal, P. Kohli, L. A. Völker, J. Dötsch, P. Nürnberg, T. Benzing, H. J. Bolz, C. Johnson, E. H. Gerkes, B. Schermer, and C. Bergmann, “Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression,” Hum. Mol. Genet., vol. 22, no. 11, pp. 2177–2185, 2013.

Gharbi, H., F. Fabretti, P. Bharill, M. M. Rinschen, S. Brinkkötter, P. Frommolt, V. Burst, B. Schermer, T. Benzing, and R. U. Müller, “Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner,” Aging Cell, vol. 12, no. 4, pp. 593–603, 2013.

Hess, M.E., S. Hess, K. D. Meyer, L. a W. Verhagen, L. Koch, H. S. Brönneke, M. O. Dietrich, S. D. Jordan, Y. Saletore, O. Elemento, B. F. Belgardt, T. Franz, T. L. Horvath, U. Rüther, S. R. Jaffrey, P. Kloppenburg, and J. C. Brüning, “The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.,” Nat. Neurosci., vol. 16, no. 8, pp. 1042–8, 2013.

Karra, E., O. G. O’Daly, A. I. Choudhury, A. Yousseif, S. Millership, M. T. Neary, W. R. Scott, K. Chandarana, S. Manning, M. E. Hess, H. Iwakura, T. Akamizu, Q. Millet, C. Gelegen, M. E. Drew, S. Rahman, J. J. Emmanuel, S. C. R. Williams, U. U. Rüther, J. C. Brüning, D. J. Withers, F. O. Zelaya, and R. L. Batterham, “A link between FTO, ghrelin, and impaired brain food-cue responsivity,” J. Clin. Invest., vol. 123, no. 8, pp. 3539–3551, 2013.

Keupp, K., F. Beleggia, H. Kayserili, A. M. Barnes, M. Steiner, O. Semler, B. Fischer, G. Yigit, C. Y. Janda, J. Becker, S. Breer, U. Altunoglu, J. Grünhagen, P. Krawitz, J. Hecht, T. Schinke, E. Makareeva, E. Lausch, T. Cankaya, J. A. Caparrós-Martín, P. Lapunzina, S. Temtamy, M. Aglan, B. Zabel, P. Eysel, F. Koerber, S. Leikin, K. C. Garcia, C. Netzer, E. Schönau, V. L. Ruiz-Perez, S. Mundlos, M. Amling, U. Kornak, J. Marini, and B. Wollnik, “Mutations in WNT1 cause different forms of bone fragility,” Am. J. Hum. Genet., vol. 92, no. 4, pp. 565–574, 2013.

Kornfeld, J.-W., C. Baitzel,  a C. Könner, H. T. Nicholls, M. C. Vogt, K. Herrmanns, L. Scheja, C. Haumaitre, A. M. Wolf, U. Knippschild, J. Seibler, S. Cereghini, J. Heeren, M. Stoffel, and J. C. Brüning, “Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.,” Nature, vol. 494, no. 7435, pp. 111–5, 2013.

Lal, D., H. Trucks, R. S. Møller, H. Hjalgrim, B. P. C. Koeleman, C. G. F. De Kovel, F. Visscher, Y. G. Weber, H. Lerche, F. Becker, C. J. Schankin, B. A. Neubauer, R. Surges, W. S. Kunz, F. Zimprich, A. Franke, T. Illig, J. S. Ried, C. Leu, P. Nürnberg, T. Sander, et al., “Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy,” Epilepsia, vol. 54, no. 2, pp. 265–271, 2013.

Lal, D., K. Becker, S. Motameny, J. Altmüller, H. Thiele, P. Nürnberg, U. Ahting, B. Rolinski, B. A. Neubauer, and A. Hahn, “Homozygous missense mutation of NDUFV1 as the cause of infantile bilateral striatal necrosis,” Neurogenetics, vol. 14, no. 1. pp. 85–87, 2013.

Lal, D., E. M. Reinthaler, J. Altmüller, M. R. Toliat, H. Thiele, P. Nürnberg, H. Lerche, A. Hahn, R. S. Møller, H. Muhle, T. Sander, F. Zimprich, and B. A. Neubauer, “RBFOX1 and RBFOX3 Mutations in Rolandic Epilepsy,” PLoS One, vol. 8, no. 9, 2013.

Lemke, J. R., D. Lal, E. M. Reinthaler, I. Steiner, M. Nothnagel, M. Alber, K. Geider, B. Laube, M. Schwake, K. Finsterwalder, A. Franke, M. Schilhabel, J. A. Jähn, H. Muhle, R. Boor, W. Van Paesschen, R. Caraballo, N. Fejerman, S. Weckhuysen, P. De Jonghe, J. Larsen, R. S. Møller, H. Hjalgrim, L. Addis, S. Tang, E. Hughes, D. K. Pal, K. Veri, U. Vaher, T. Talvik, P. Dimova, et al., “Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.,” Nat. Genet., vol. 45, no. 9, pp. 1067–72, 2013.

Mullen, S. A., G. L. Carvill, S. Bellows, M. A. Bayly, H. Trucks, D. Lal, T. Sander, S. F. Berkovic, L. M. Dibbens, I. E. Scheffer, and C. Mefford, H, “Copy number variants are frequent in genetic generalized epilepsy with intellectual disability,” Neurology, vol. 81, no. 17, pp. 1507–1514, 2013.

Müller, R., C. Herr, S. K. Sukumaran, N. N. Omosigho, M. Plomann, T. Y. Riyahi, M. Stumpf, K. Swaminathan, M. Tsangarides, K. Yiannakou, R. Blau-Wasser, C. Gallinger, M. Schleicher, W. Kolanus, and A. a Noegel, “The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.,” Cell Commun. Signal., vol. 11, p. 54, 2013.

Newton, A. J., S. Hess, L. Paeger, M. C. Vogt, J. F. Lascano, E. A. Nillni, J. C. Brüning, P. Kloppenburg, and A. W. Xu, “AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice,” Endocrinology, vol. 154, no. 1, pp. 172–183, 2013.

Niessen, M. T., J. Scott, J. G. Zielinski, S. Vorhagen, P. A. Sotiropoulou, C. Blanpain, M. Leitges, and C. M. Niessen, “Apkcγ controls epidermal homeostasis and stemcell fate through regulation of division orientation,” J. Cell Biol., vol. 202, no. 6, pp. 887–900, 2013.

Pohl, E., A. Aykut, F. Beleggia, E. Karaca, B. Durmaz, K. Keupp, E. Arslan, M. P. Onay, G. Yigit, F. Özkinay, and B. Wollnik, “A hypofunctional PAX1 mutation causes autosomal recessively inherited otofaciocervical syndrome,” Hum. Genet., vol. 132, no. 11, pp. 1311–1320, 2013.

Potting, C., T. Tatsuta, T. König, M. Haag, T. Wai, M. J. Aaltonen, and T. Langer, “TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid,” Cell Metab., vol. 18, no. 2, pp. 287–295, 2013.

Rossi, M., S. Duan, Y. T. Jeong, M. Horn, A. Saraf, L. Florens, M. P. Washburn, A. Antebi, and M. Pagano, “Regulation of the CRL4Cdt2 ubiquitin ligase and Cell-Cycle exit by the SCFFbxo11 ubiquitin ligase,” Mol. Cell, vol. 49, no. 6, pp. 1159–1166, 2013.

Steculorum, S. M., M. C. Vogt, and J. C. Brüning, “Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits,” Endocrinology and Metabolism Clinics of North America, vol. 42, no. 1. pp. 149–164, 2013.

Vogt, M. C. and J. C. Brüning, “CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age,” Trends Endocrinol. Metab., vol. 24, no. 2, pp. 76–84, 2013.

Wieczorek, D., N. Bögershausen, F. Beleggia, S. Steiner-Haldenstätt, E. Pohl, Y. Li, E. Milz, M. Martin, H. Thiele, J. Altmüller, Y. Alanay, H. Kayserili, L. Klein-Hitpass, S. Böhringer, A. Wollstein, B. Albrecht, K. Boduroglu, A. Caliebe, K. Chrzanowska, O. Cogulu, F. Cristofoli, J. C. Czeschik, K. Devriendt, M. T. Dotti, N. Elcioglu, B. Gener, T. O. Goecke, M. Krajewska-Walasek, , et al., “A comprehensive molecular study on coffin-siris and nicolaides-baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling,” Hum. Mol. Genet., vol. 22, no. 25, pp. 5121–5135, 2013.

Yüncü, E., S. Demirci, E. Koban Baştanlar, Ş. A. Doǧan, U. Taşdemir, and N. Togan, “Comparative study of three simple molecular approaches in search of mtDNA haplogroup identification of domestic sheep,” Small Rumin. Res., vol. 114, no. 1, pp. 64–71, 2013.


Thier, M., P. Wörsdörfer, Y. B. Lakes, R. Gorris, S. Herms, T. Opitz, D. Seiferling, T. Quandel, P. Hoffmann, M. M. Nöthen, O. Brüstle, and F. Edenhofer, “Direct conversion of fibroblasts into stably expandable neural stem cells,” Cell Stem Cell, vol. 10, no. 4, pp. 473–479, 2012.

Zeller, E., K. Mock, M. Horn, S. Colnot, M. Schwarz, and A. Braeuning, “Dual-specifi city phosphatases are targets of the Wnt/β-catenin pathway and candidate mediators of β-catenin/Ras signaling interactions,” Biol. Chem., vol. 393, no. 10, pp. 1183–1191, 2012.



Dogan, S. A. and A. Trifunovic, “Modelling mitochondrial dysfunction in mice.,” Physiol. Res., vol. 60 Suppl 1, pp. S61-70, 2011.

Hou, Y. Y., H. L. Ou, S. T. Chu, P. C. Wu, P. J. Lu, C. C. Chi, K. W. Leung, C. Y. Lee, P. H. Wu, M. Hsiao, and L. P. Ger, “NAT2 slow acetylation haplotypes are associated with the increased risk of betel quidrelated oral and pharyngeal squamous cell carcinoma,” Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology, vol. 112, no. 4, pp. 484–492, 2011.

Kukat, A., D. Edgar, I. Bratic, P. Maiti, and A. Trifunovic, “Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts,” Biochem. Biophys. Res. Commun., vol. 409, no. 3, pp. 394–399, 2011.

Yabas, M., C. E. Teh, S. Frankenreiter, D. Lal, C. M. Roots, B. Whittle, D. T. Andrews, Y. Zhang, N. C. Teoh, J. Sprent, E. Tze, E. M. Kucharska, J. Kofler, G. C. Farell, and S. Bröer, “ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation,” Nat Immunol., vol. 12, no. 5, pp. 441–449, 2011.



Kruttwig, K., C. Brueggemann, E. Kaijzel, S. Vorhagen, T. Hilger, C. Löwik, and M. Hoehn, “Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: monitoring by magnetic resonance imaging and optical imaging.,” Mol. imaging Biol., vol. 12, no. 4, pp. 367–76, 2010.

Wu, Y.-L., Y. R. Kou, H.-L. Ou, H.-Y. Chien, K.-H. Chuang, H.-H. Liu, T.-S. Lee, C.-Y. Tsai, and M.-L. Lu, “Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells,” Eur. J. Pharmacol., vol. 635, no. 1–3, pp. 219–226, 2010.



Follmann, M., I. Ochrombel, R. Krämer, C. Trötschel, A. Poetsch, C. Rückert, A. Hüser, M. Persicke, D. Seiferling, J. Kalinowski, and K. Marin, “Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis.,” BMCGenomics, vol. 10, p. 621, 2009.