Ageing is a complex process that is influenced by an organism’s genetic makeup and its environment. Why almost all organisms age is incompletely understood, and we know much less about potential ways to decelerate this process. A better understanding of the biology of ageing is particularly important as age-associated diseases are becoming more prevalent in increasingly older populations.
We are implementing a number of forward genetic screening approaches to identify mechanisms that modulate the rate of ageing. We then aim to understand the underlying biology using molecular and biochemical approaches. Past work has identified the metabolic hexosamine pathway as a novel regulator of protein quality control and organismal ageing. While pursuing this line of research, we have found additional genetic modulators of the aging process specifically in the regulation of protein synthesis.
I am seeking a self-motivated and driven Ph.D. student to join a small team within the lab that investigates the role of mRNA translation in new long-lived mutants that we generated in C. elegans. Background training in C. elegans genetics and biochemical assays are desirable but not a must.