Research

Principle investigators of the Cologne Graduate School of Ageing Research (CGA) are internationally recognized scientists known for their cutting edge research into diverse topics including genetic determinants of longevity, protein quality control, DNA damage and repair, mitochondria regulation, immunosenescence and inflammation, stem cell and tissue maintenance, organellar and cellular architecture, endocrine control of metabolism, as well as their research into age-related diseases such as neurodegeneration, cancer, diabetes, obesity, kidney dysfunction. Close links between the research groups foster interdisciplinary collaboration and promote the development of novel research approaches.

The laboratories use diverse model systems - from bacteria, yeast, worms, and flies, to fish, mice, cultured cells, and human clinical samples - to delve into basic mechanistic questions. Core facilities provide on-campus platforms for performing genomics, proteomics, lipidomics, imaging, cell sorting, metabolic profiling and phenotyping.

Principle Investigators and their Research Areas

Prof. Adam Antebi

Managing Director MPI for Biology of Ageing
Molecular Genetics of Ageing
www.age.mpg.de/the-science/research-labs/antebi/

Dr. Hisham Bazzi

CECAD Junior Group
Cytoskeletal organizers in mammalian development and homeostasis
cecad.uni-koeln.de/Dr-Hisham-Bazzi.422.0.html

Prof. Thomas Benzing

Director of Department II of Internal Medicine and Center for Molecular Medicine Cologne
Kidney Research
www.kidneyresearchcenter.org

Dr. Matteo Bergami

CECAD Junior Group
Mechanisms of neuronal de- and regeneration
cecad.uni-koeln.de/Dr-Matteo-Bergami.323.0.html

Prof. Andreas Beyer

Professor for Systems Biology at the University of Cologne
Cellular networks and systems biology
cellnet.cecad.uni-koeln.de

Prof. Jens C. Brüning

CECAD Coordinator, Head of Research Area F, Managing Director of MPI for Metabolism Research
Neuronal control of metabolism and ageing
cecad.uni-koeln.de/Prof-Jens-C-Bruening.75.0.html

Prof. Oliver A. Cornely

CECAD Head of Platform C
Translation
Translation of clinical research findings into practical applications
cecad.uni-koeln.de/Prof-Oliver-Cornely.79.0.html

Dr. Constantinos Demetriades

MPI for Biology of Ageing
Cell Growth control in Health and age-related Disease
https://www.age.mpg.de/science/research-labs/demetriades/

Dr. Martin Denzel

MPI for Biology of Ageing
Metabolic and Genetic Regulation of Ageing
www.age.mpg.de/science/research-labs/denzel/

Dr. Martin Graef

MPI for Biology of Ageing
Effectors and Regulation of Autophagy during Ageing
www.age.mpg.de/science/research-labs/graef/

Prof. Michael Hallek

Department for Internal Medicine I and CIO
Identification of therapeutic potential for the treatment of immunologic disorders and hematologic malignancies
cecad.uni-koeln.de/Prof-Michael-Hallek.77.0.html

Prof. Matthias Hammerschmidt

Cologne Biocenter, Institute of Developmental Biology
Regulators of obesity or anorexia in zebrafish
cecad.uni-koeln.de/Prof-Matthias-Hammerschmidt.80.0.html

Dr. Hans Christian Hennies

Cologne Center for Genomics, Center for Molecular Medicine Cologne
Mechanisms of ageing in genetic skin and connective tissue diseases
cecad.uni-koeln.de/Dr-Hans-Christian-Hennies.90.0.html

Dr. Marco Herling

Department of Internal Medicine I
Aberrant signaling in malignant lymphocyte
innere1.uk-koeln.de/research/lab-lymphocyte-signaling-and-oncoproteome

Prof. Thorsten Hoppe

CECAD Head of Research Area B, Institute for Genetics 
Proteostasis in Development and Ageing
cecad.uni-koeln.de/Prof-Thorsten-Hoppe.92.0.html

Dr. Sandra Iden

CECAD, Center for Molecular Medicine Cologne (CMMC)
Cell Polarity in Tissue Homeostasis and Cancer
iden.cecad-labs.de

Dr. Hamid Kashkar

Institute for Medical Microbiology, Immunology and Hygiene (IMMIH)
Cell Death and Immunity
immih.uk-koeln.de/forschung/ag-kashkar

Prof. U. Benjamin Kaupp

Managing Director caesar
Molecular Sensory Systems
www.caesar.de/molekulare-neurosensorik.html

Prof. Peter Kloppenburg

Cologne Biocenter, Zoological Institute
Analysis of biophysical parameters and cellular mechanisms controlling energy homeostasis
cecad.uni-koeln.de/Prof-Peter-Kloppenburg.82.0.html

Dr. Natalia Kononenko

CECAD Junior Group
Molecular and cellular mechanisms of neurodegeneration
cecad.uni-koeln.de/Dr-Natalia-Kononenko.435.0.html

Dr. Jan-Wilhelm Kornfeld

MPI for Metabolism Research
Noncoding RNAs and Energy Homeostasis
www.kornfeldlab.com

Prof. Thomas Krieg

Department of Dermatology
Development of innovative treatments of disturbed wound-healing processes and skin cancer
cecad.uni-koeln.de/Prof-Thomas-Krieg.83.0.html

Prof. Martin Krönke

CECAD Head of Research Area D, Institute for Medical Microbiology, Immunology and Hygiene (IMMIH) 
Altered signaling functions of the aged membrane
cecad.uni-koeln.de/Prof-Martin-Kroenke.95.0.html

Dr. Leo Kurian

Independent group leader (NRW stem cell network), Institute for Neurophysiology, Center for Molecular Medicine and CECAD
Long non-coding RNAs in programming and reprogramming cellular identities during development, regeneration and ageing
www.lklab.de

Dr. Michael Lammers

Institute for Genetics, CECAD Research Center
Cytoskeleton regulation by post-translational lysine-acetylation
cecad.uni-koeln.de/Dr-Michael-Lammers.94.0.html

Prof. Thomas Langer

CECAD Vice-Spokesperson, Head of Research Area A, Institute for Genetics 
Mitochondrial function, quality control and neurodegeneration
cecad.uni-koeln.de/Prof-Thomas-Langer.98.0.html

Prof. Nils-Göran Larsson

Director MPI for Biology of Ageing
Mitochondrial dysfunction in ageing and disease
www.age.mpg.de/science/research-labs/larsson/

Dr. Ivan Matic

MPI for Biology of Ageing; CECAD Junior Research Group
Proteomics of post-translational modifications
www.age.mpg.de/science/research-labs/matic/

Prof. Carien Niessen

CECAD Head of Platform for Education, Career Development and Gender Equality Programs
Cell architecture in tissue homeostasis, ageing and disease
www.niessenlab.uni-koeln.de

Prof. Angelika Noegel

Institute for Biochemistry I 
The role of the nuclear envelope
cecad.uni-koeln.de/Prof-Angelika-A-Noegel.101.0.html

Prof. Peter Nürnberg

Cologne Center for Genomics
Investigation of the pathology of DC and processes of abnormal fibroblast differentiation
portal.ccg.uni-koeln.de/ccg/

Prof. Linda Partridge

Director MPI for Biology of Ageing
Biological Mechanisms of Ageing
www.age.mpg.de/the-science/research-labs/partridge/

Prof. Manolis Pasparakis

CECAD Head of Research Area E, Institute for Genetics 
Cell death and inflammation in tissue homeostasis and disease
cecad.uni-koeln.de/Prof-Manolis-Pasparakis.102.0.html

Prof. Mats Paulsson

Institute for Biochemistry II 
Biological Functions of the Extracellular Matrix
cecad.uni-koeln.de/Prof-Mats-Paulsson.103.0.html

Dr. Alvaro Rada-Iglesias

Junior Research Group Leader
Developmental Genomics
zmmk-ari.uni-koeln.de/Rada-Iglesias_lab___Developmental_genomics/Home.html

Prof. Christian Reinhardt

CECAD Head of Research Area C, Department of Internal Medicine I, Division I, Hematology/Oncology 
Targeting the DNA damage response for personalized cancer therapy
cecad.uni-koeln.de/Prof-H-Christian-Reinhardt.140.0.html
innere1.uk-koeln.de/research/oncogene-signaling-and-chemotherapy-response

Dr. Nirmal Robinson

Institute for Medical Microbiology and Immunology
Innate Immunesenescence
cecad.uni-koeln.de/Dr-Nirmal-Robinson.270.0.html

Prof. Elena I. Rugarli

Institute for Genetics
Pathogenic Mechanisms of Axonal Degeneration
www.neuro.uni-koeln.de/neuro-rugarli.html

Prof. Bernhard Schermer

Head of Nephrolab Cologne
Kidney Research
www.kidneyresearchcenter.org

Prof. Björn Schumacher

Chair for Genome Stability in Ageing and Disease
DNA Damage and Ageing
www.uni-koeln.de/inter-fak/cecad/schumacher/

Prof. Günter Schwarz

Chair in Biochemistry
Biochemical and Cellular Neuroscience
www.schwarzlab.uni-koeln.de

Dr. Philipp Steven

Zentrum für Augenheilkunde
Therapeutic approaches of defects caused by dry-eye disease
cecad.uni-koeln.de/Dr-Phillip-Steven.340.0.html

Dr. James Stewart

MPI for Biology of Ageing
Genome Evolution and Ageing
www.age.mpg.de/de/forschung/arbeitsgruppen/stewart/

Prof. Wilhelm Stoffel

Center for Molecular Medicine Cologne
researching the systemic and/or cell specific role of phospholipids substituted with mono- and polyunsaturated fatty acid (PUFAs) in cell membrane organization and function
cecad.uni-koeln.de/Prof-Wilhelm-Stoffel.109.0.html

Dr. Peter Tessarz

MPI for Biology of Ageing
Chromatin and Ageing
www.age.mpg.de/science/research-labs/tessarz/

Prof. Aleksandra Trifunovic

Institute for Mitochondrial Diseases and Ageing / Medical Faculty
Understanding the role of mitochondrial (dys)function in the determination of longevity
www.uni-koeln.de/inter-fak/cecad/trifunovic/index.html

Prof. Mirka Uhlirova

Institute for Genetics
Stress signalling development and disease
www.uni-koeln.de/inter-fak/cecad/uhlirova/

Dr. Dario Valenzano

MPI for Biology of Ageing
Evolutionary and Experimental Biology of Ageing
www.age.mpg.de/science/research-labs/valenzano/

Dr. David Vilchez

CECAD Junior Group
Proteostasis of Ageing and Stem Cells
www.vilchezlab.com

Dr. Dagmar Wachten

Max Planck Research Group Leader, caesar
Molecular mechanisms underlying physiological functions in health and disease
http://www.caesar.de/1289.html?&L=0

Dr. Sara Wickström

MPI for Biology of Ageing
Skin Homeostasis and Ageing
www.age.mpg.de/science/research-labs/wickstroem/

Prof. Rudolf J. Wiesner

Institute for Vegetative Physiology
Mitochondrial DNA Mutations and Mitochondrial Dysfunction in Ageing
cecad.uni-koeln.de/Prof-Rudolf-J-Wiesner.115.0.html

Dr. Thomas Wunderlich

MPI for Metabolism Research
Mouse genetics and obesity-associated cancer
www.genetik.uni-koeln.de/groups/Wunderlich/index.htm

Dr. Xiangru Xu

MPI for Biology of Ageing
Epigenetic Regulation of Mammalian Ageing
www.age.mpg.de/science/research-labs/xu/